4-(1-PIPERIDINYLMETHYL)PHENYLBORONIC ACID

Base Information

• Chemical Name: 4-(1-PIPERIDINYLMETHYL)PHENYLBORONIC ACID
• CAS No.: 1200434-84-9
• Molecular Formula: C₁₂H₁₈BNO₂
• Molecular Weight: 219.091
• Hs Code.: 2933399990
• Mol file: 1200434-84-9.mol

Synonyms:(4-(piperidin-1-ylmethyl)phenyl)boronic acid

Chemical Property of 4-(1-PIPERIDINYLMETHYL)PHENYLBORONIC ACID

Chemical Property:

• Boiling Point: 368.2±44.0 °C(Predicted)
• PKA: 8.43±0.16(Predicted)
• Density: 1.13±0.1 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

4-(1-Piperidylmethyl)phenylboronic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(1-PIPERIDINYLMETHYL)PHENYLBORONIC ACID

There total 1 articles about 4-(1-PIPERIDINYLMETHYL)PHENYLBORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperidine (110-89-4) + 4-bromomethylphenylboronic acid (68162-47-0) → (4-(piperidin-1-ylmethyl)phenyl)boronic acid (1200434-84-9)

Guidance literature:

With potassium carbonate; sodium iodide; In acetonitrile; at 50 ℃; for 2h;

Reference yield: 100.0%

2-bromothiazole-4-carbaldehyde (5198-80-1) + (4-(piperidin-1-ylmethyl)phenyl)boronic acid (1200434-84-9) → 2-(4-(piperidin-1-ylmethyl)phenyl)thiazole-4-carbaldehyde

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; ethanol; at 100 ℃; for 24h;

DOI:10.1016/j.bmc.2017.02.056

Reference yield: 91.0%

methyl 3-bromo-9H-pyrrolo[2,3-b:5,4-c′]dipyridine-6-carboxylate (1200130-50-2) + (4-(piperidin-1-ylmethyl)phenyl)boronic acid (1200434-84-9) → methyl 3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]dipyridine-6-carboxylate

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; acetonitrile; at 120 ℃; for 0.5h; Microwave irradiation;

DOI:10.1021/acs.jmedchem.5b00464

upstream raw materials:

piperidine

4-bromomethylphenylboronic acid

Downstream raw materials:

6-(4-piperidin-1-ylmethylphenyl)-1H-pyrrolo[2,3-b]pyridine

6-(4-Piperidin-1-ylmethylphenyl)pyrrolo[2,3-b]pyridine-1-carboxylic acid amide

3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]-dipyridine-6-carbonitrile

6-bromo-3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]dipyridine

Refernces