5-(2,4-DIFLUOROPHENYL)-3-ISOXAZOLEMETHANOL

Base Information

• Chemical Name: 5-(2,4-DIFLUOROPHENYL)-3-ISOXAZOLEMETHANOL
• CAS No.: 934188-81-5
• Molecular Formula: C10H7F2NO2
• Molecular Weight: 211.168
• Mol file: 934188-81-5.mol

Synonyms:5-(2,4-DIFLUOROPHENYL)-3-ISOXAZOLEMETHANOL;[5-(2,4-Difluorophenyl)isoxazol-3-yl]methanol

Chemical Property of 5-(2,4-DIFLUOROPHENYL)-3-ISOXAZOLEMETHANOL

Chemical Property:

• Boiling Point: 340.4±37.0 °C(Predicted)
• PKA: 12.94±0.10(Predicted)
• PSA: 46.26000
• Density: 1.380±0.06 g/cm3(Predicted)
• LogP: 2.11210

Purity/Quality:

NLT 98% ^*data from raw suppliers

[5-(2,4-difluorophenyl)isoxazol-3-yl]methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(2,4-DIFLUOROPHENYL)-3-ISOXAZOLEMETHANOL

There total 4 articles about 5-(2,4-DIFLUOROPHENYL)-3-ISOXAZOLEMETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C11H7F2NO3 (1105191-49-8) → [5-(2,4-difluorophenyl)-3-isoxazolyl]methanol (934188-81-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃;

DOI:10.3390/molecules22122000

Reference yield:

ethyl 5-(2,4-difluorophenyl)isoxazole-3-carboxylate (934188-80-4) → [5-(2,4-difluorophenyl)-3-isoxazolyl]methanol (934188-81-5)

Guidance literature:

ethyl 5-(2,4-difluorophenyl)isoxazole-3-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 ℃; for 0.166667h;

With hydrogenchloride; water; In tetrahydrofuran;

Reference yield:

2',4'-difluoroacetophenone (364-83-0) → [5-(2,4-difluorophenyl)-3-isoxazolyl]methanol (934188-81-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium methylate / methanol / 60 °C

2: hydroxylamine hydrochloride / methanol / 60 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

With lithium aluminium tetrahydride; hydroxylamine hydrochloride; sodium methylate; In tetrahydrofuran; methanol;

DOI:10.3390/molecules22122000

upstream raw materials:

ethyl 5-(2,4-difluorophenyl)isoxazole-3-carboxylate

2',4'-difluoroacetophenone

C₁₁H₈F₂O₄

C₁₁H₇F₂NO₃

Downstream raw materials:

[5-(2,4-difluorophenyl)-3-isoxazolyl]methyl acetate

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