AcetaMide, N-[2-hydroxy-1-(hydroxyMethyl)-1-(1,2,3,4-tetrahydro-6-octyl-2-naphthalenyl)ethyl]-

Base Information

• Chemical Name: AcetaMide, N-[2-hydroxy-1-(hydroxyMethyl)-1-(1,2,3,4-tetrahydro-6-octyl-2-naphthalenyl)ethyl]-
• CAS No.: 945632-83-7
• Molecular Formula: C₂₃H₃₇NO₃
• Molecular Weight: 375.552
• Hs Code.: 2924299090
• Mol file: 945632-83-7.mol

Synonyms:AcetaMide, N-[2-hydroxy-1-(hydroxyMethyl)-1-(1,2,3,4-tetrahydro-6-octyl-2-naphthalenyl)ethyl]-

Chemical Property of AcetaMide, N-[2-hydroxy-1-(hydroxyMethyl)-1-(1,2,3,4-tetrahydro-6-octyl-2-naphthalenyl)ethyl]-

Chemical Property:

• PSA: 73.05000
• LogP: 4.39430

Purity/Quality:

N-(1,3-Dihydroxy-2-(6-octyl-1,2,3,4-tetrahydronaphthalen-2-yl)propan-2-yl)acetamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AcetaMide, N-[2-hydroxy-1-(hydroxyMethyl)-1-(1,2,3,4-tetrahydro-6-octyl-2-naphthalenyl)ethyl]-

There total 8 articles about AcetaMide, N-[2-hydroxy-1-(hydroxyMethyl)-1-(1,2,3,4-tetrahydro-6-octyl-2-naphthalenyl)ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

2-acetylamino-2-(6-octyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-malonic acid diethyl ester (945632-81-5) → N-[2-hydroxy-1-hydroxymethyl-1-(6-octyl-1,2,3,4-tetrahydro-naphthalen-2-yl)ethyl]-acetamide (1118948-68-7,1118948-71-2,945632-83-7)

Guidance literature:

2-acetylamino-2-(6-octyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-malonic acid diethyl ester; With lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃; for 48h;

With water; In tetrahydrofuran; ethyl acetate;

Reference yield:

6-octyl-3,4-dihydro-2H-naphthalen-1-one (945632-75-7) → N-[2-hydroxy-1-hydroxymethyl-1-(6-octyl-1,2,3,4-tetrahydro-naphthalen-2-yl)ethyl]-acetamide (1118948-68-7,1118948-71-2,945632-83-7)

Guidance literature:

Multi-step reaction with 4 steps

1: copper(ll) bromide / chloroform; ethyl acetate / 6 h / Heating / reflux

2: N,N-dimethyl-formamide / 16 h / 20 °C

3: triethylsilane; titanium tetrachloride / dichloromethane / 12 h / 0 - 20 °C

4: lithium borohydride / tetrahydrofuran / 48 h / 0 - 20 °C

With triethylsilane; lithium borohydride; titanium tetrachloride; copper(ll) bromide; In tetrahydrofuran; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

2-bromo-6-octyl-3,4-dihydro-2H-naphthalen-1-one (945632-77-9) → N-[2-hydroxy-1-hydroxymethyl-1-(6-octyl-1,2,3,4-tetrahydro-naphthalen-2-yl)ethyl]-acetamide (1118948-68-7,1118948-71-2,945632-83-7)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 16 h / 20 °C

2: triethylsilane; titanium tetrachloride / dichloromethane / 12 h / 0 - 20 °C

3: lithium borohydride / tetrahydrofuran / 48 h / 0 - 20 °C

With triethylsilane; lithium borohydride; titanium tetrachloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

2-acetylamino-2-(6-octyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-malonic acid diethyl ester

6-octyl-3,4-dihydro-2H-naphthalen-1-one

2-bromo-6-octyl-3,4-dihydro-2H-naphthalen-1-one

2-acetylamino-2-(6-octyl-1-oxo-1,2,3,4-tetrahydro-naphthalen-2-yl)-malonic acid diethyl ester

Downstream raw materials:

2-amino-2-(6-octyl-1,2,3,4-tetrahydro-naphthalen-2-yl)propane-1,3-diol

Refernces

• 1、 -. "BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS". Page/Page column 33. . Retrieved 2008/06/13.