(2S,5R)-1,2,5-triMethylpiperazine

Base Information

• Chemical Name: (2S,5R)-1,2,5-triMethylpiperazine
• CAS No.: 1152367-85-5
• Molecular Formula: C₇H₁₆N₂
• Molecular Weight: 128.217
• Mol file: 1152367-85-5.mol

Synonyms:(2S,5R)-1,2,5-triMethylpiperazine;(2S,5R)-1,2,5-TriMethylpiperazine oxalate

Chemical Property of (2S,5R)-1,2,5-triMethylpiperazine

Chemical Property:

• PSA: 15.27000
• LogP: 0.56510
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(2S,5R)-1,2,5-Trimethylpiperazine oxalate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S,5R)-1,2,5-triMethylpiperazine

There total 3 articles about (2S,5R)-1,2,5-triMethylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-2r,4,5t-trimethyl-piperazine-1-carboxylic acid ethyl ester (24779-46-2,24779-47-3) → (+/-)-1,2r,5t-trimethyl-piperazine (24779-48-4,24779-49-5,82546-86-9,1152367-85-5)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01123a008

Reference yield:

ethyl trans-2,5-dimethyl-1-piperazinecarboxylate (24779-44-0,24779-45-1,872829-56-6) → (+/-)-1,2r,5t-trimethyl-piperazine (24779-48-4,24779-49-5,82546-86-9,1152367-85-5)

Guidance literature:

Multi-step reaction with 2 steps

1: formic acid

2: aqueous HCl

With hydrogenchloride; formic acid;

DOI:10.1021/ja01123a008

Reference yield:

2,5-dimethyl-piperazine (2815-34-1,1119702-25-8) → (+/-)-1,2r,5t-trimethyl-piperazine (24779-48-4,24779-49-5,82546-86-9,1152367-85-5)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous solution by/at pH 3-3.6

2: formic acid

3: aqueous HCl

With hydrogenchloride; formic acid; solution by;

DOI:10.1021/ja01123a008

upstream raw materials:

(+/-)-2r,4,5t-trimethyl-piperazine-1-carboxylic acid ethyl ester

ethyl trans-2,5-dimethyl-1-piperazinecarboxylate

2,5-dimethyl-piperazine