ethyl trans-2,5-dimethyl-1-piperazinecarboxylate

Base Information

• Chemical Name: ethyl trans-2,5-dimethyl-1-piperazinecarboxylate
• CAS No.: 24779-44-0
• Molecular Formula: C₉H₁₈N₂O₂
• Molecular Weight: 186.254
• Mol file: 24779-44-0.mol

Synonyms:

Chemical Property of ethyl trans-2,5-dimethyl-1-piperazinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl trans-2,5-dimethyl-1-piperazinecarboxylate

There total 4 articles about ethyl trans-2,5-dimethyl-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

chloroformic acid ethyl ester (541-41-3) + 2,5-dimethyl-piperazine (2815-34-1,1119702-25-8) → ethyl trans-2,5-dimethyl-1-piperazinecarboxylate (24779-44-0,24779-45-1,872829-56-6)

Guidance literature:

With methanesulfonic acid; potassium acetate; In tetrahydrofuran; at 25 ℃; for 1h;

DOI:10.1002/jhet.5570320622

Reference yield:

chloroformic acid ethyl ester (541-41-3) + 2,5-dimethyl-piperazine (2815-34-1,1119702-25-8) → 2r,5t-dimethyl-piperazine-1,4-dicarboxylic acid diethyl ester (6286-18-6,96424-14-5) + ethyl trans-2,5-dimethyl-1-piperazinecarboxylate (24779-44-0,24779-45-1,872829-56-6)

Guidance literature:

With aqueous solution of pH 3-3.5;

DOI:10.1021/jo50017a003 DOI:10.1021/ja01123a008

Reference yield:

→ trans-2,5-Dimethyl-N-carbethoxy-piperazin (24779-44-0,24779-45-1,872829-56-6)

Guidance literature:

trans-2,5-Dimethylpiperazin, wss. HCl, Chlorameisensaeureethylester;

upstream raw materials:

chloroformic acid ethyl ester

2,5-dimethyl-piperazine

Downstream raw materials:

(-)-3-((R)-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)(4-bromo-2-thienyl)methyl)phenol