(S)-4-(2,7-dichloropyrido[2,3-d]pyriMidin-4-yl)-3-MethylMorpholine

Base Information

Chemical Name:(S)-4-(2,7-dichloropyrido[2,3-d]pyriMidin-4-yl)-3-MethylMorpholine
CAS No.:1009303-42-7
Molecular Formula:C12H12Cl2N4O
Molecular Weight:299.159
Hs Code.:
Mol file:1009303-42-7.mol

Synonyms:(S)-4-(2,7-dichloropyrido[2,3-d]pyriMidin-4-yl)-3-MethylMorpholine

Suppliers and Price of (S)-4-(2,7-dichloropyrido[2,3-d]pyriMidin-4-yl)-3-MethylMorpholine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-4-(2,7-Dichloropyrido[2,3-d]pyrimidin-4-yl)-3-methylmorpholine
10mg
$ 90.00

Chemenu
(S)-4-(2,7-dichloropyrido[2,3-d]pyrimidin-4-yl)-3-methylmorpholine 95%+
1g
$ 1237.00

Chemenu
(S)-4-(2,7-dichloropyrido[2,3-d]pyrimidin-4-yl)-3-methylmorpholine 95%+
250mg
$ 928.00

Chemenu
(S)-4-(2,7-dichloropyrido[2,3-d]pyrimidin-4-yl)-3-methylmorpholine 95%+
100mg
$ 402.00

Total 7 raw suppliers

Chemical Property of (S)-4-(2,7-dichloropyrido[2,3-d]pyriMidin-4-yl)-3-MethylMorpholine

Chemical Property:

Boiling Point:429.1±45.0 °C(Predicted)
PKA:1.69±0.30(Predicted)
PSA：51.14000
Density:1.421±0.06 g/cm3(Predicted)
LogP:2.62170

Purity/Quality:

NLT 98% ^*data from raw suppliers

(S)-4-(2,7-Dichloropyrido[2,3-d]pyrimidin-4-yl)-3-methylmorpholine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (S)-4-(2,7-dichloropyrido[2,3-d]pyriMidin-4-yl)-3-MethylMorpholine

There total 1 articles about (S)-4-(2,7-dichloropyrido[2,3-d]pyriMidin-4-yl)-3-MethylMorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64321-24-0
2-amino-6-chloro-pyridine-3-carboxamide

: 1009303-42-7
(S)-4-(2,7-dichloropyrido[2,3-d]pyrimidin-4-yl)-3-methylmorpholine

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 115 °C

2: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 100 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dichloromethane; toluene;
DOI:10.1016/j.bmcl.2013.01.019

Reference yield: 93.0%

: 13780-71-7
dihydroxyborane

: 14221-01-3
tetrakis(triphenylphosphine) palladium⁽⁰⁾

: 1009303-42-7
(S)-4-(2,7-dichloropyrido[2,3-d]pyrimidin-4-yl)-3-methylmorpholine

: 1009303-54-1
{5-[2-Chloro-4-((R)-3-methyl-morpholin-4-yl)-pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-phenyl}-methanol

Guidance literature:: With potassium carbonate; In methanol; dichloromethane; water; acetonitrile;

Reference yield: 78.0%

: 1009303-42-7
(S)-4-(2,7-dichloropyrido[2,3-d]pyrimidin-4-yl)-3-methylmorpholine

: 908142-03-0
(3-(hydroxymethyl)-4-methoxy)phenylboronic acid

: 1009303-74-5
(S)-(5-(2-chloro-4-(3-methylmorpholinyl)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; acetonitrile; at 95 ℃; for 2h; Product distribution / selectivity;