[1,1'-Biphenyl]-3-aMine, 4,4'-difluoro-

Base Information

• Chemical Name: [1,1'-Biphenyl]-3-aMine, 4,4'-difluoro-
• CAS No.: 323-93-3
• Molecular Formula: C12H9F2N
• Molecular Weight: 205.2033664
• Mol file: 323-93-3.mol

Synonyms:[1,1'-Biphenyl]-3-aMine, 4,4'-difluoro-;4,4'-difluorobiphenyl-3-aMine

Chemical Property of [1,1'-Biphenyl]-3-aMine, 4,4'-difluoro-

Chemical Property:

• PSA: 26.02000
• LogP: 3.79520

Purity/Quality:

98%min ^*data from raw suppliers

4,4'-Difluorobiphenyl-3-amine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1,1'-Biphenyl]-3-aMine, 4,4'-difluoro-

There total 1 articles about [1,1'-Biphenyl]-3-aMine, 4,4'-difluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-fluoroboronic acid (1765-93-1) + 5-bromo-2-fluoroaniline (2924-09-6) → C12H9F2N (323-93-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; toluene; for 24h; Reflux;

Reference yield: 32.0%

o-fluorobromobenzene (1072-85-1) + C12H9F2N (323-93-3) → C18H12F3N (1453206-12-6)

Guidance literature:

With tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate; In toluene; for 12h; Inert atmosphere; Reflux;

Reference yield:

C12H9F2N (323-93-3) → C52H30F6N2 (1453206-22-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate / toluene / 12 h / Inert atmosphere; Reflux

2: tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate / toluene / 12 h / Inert atmosphere; Reflux

With tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate; In toluene;

upstream raw materials:

4-fluoroboronic acid

5-bromo-2-fluoroaniline

Downstream raw materials:

C₅₂H₃₀F₆N₂

C₁₈H₁₂F₃N

Refernces