2924-09-6

Basic information

• Product Name: 5-BROMO-2-FLUOROANILINE
• Synonyms: 5-BROMO-2-FLUOROANILINE;2-Fluoro-5-Bromoaniline;5-Bromo-2-fluoro Aniline 2924-9-6;5-Bromo-2-fluoroaniline ,98%;5-BROMO-2-FLUOROANIL;1-Amino-5-bromo-2-fluorobenzene;Benzenamine, 5-bromo-2-fluoro-;5-Bromo-2-fuoroaniline
• CAS NO: 2924-09-6
• Molecular Formula: C₆H₅BrFN
• Molecular Weight: 190.01
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Phenol&Thiophenol&Mercaptan;Benzenes;Aniline series
• Mol File: 2924-09-6.mol
• Article Data: 17

Chemical Properties

• Melting Point: 27℃
• Boiling Point: 105 °C / 12mmHg
• Flash Point: 27 °C
• Appearance: /Solid
• Density: 1.694 g/cm³
• Vapor Pressure: 0.0843mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.13±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 5-BROMO-2-FLUOROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-FLUOROANILINE(2924-09-6)
• EPA Substance Registry System: 5-BROMO-2-FLUOROANILINE(2924-09-6)

Safety Data

• Hazard Codes: T,Xi,Xn
• Statements: 22-36-52-36/37/38-20/21/22
• Safety Statements: 26-60-36/37-9
• RIDADR: 2811
• HazardClass: IRRITANT, TOXIC
• Hazardous Substances Data: 2924-09-6(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow solid

Uses

5-Bromo-2-fluoroaniline is used as pharmaceutical intermediate.

InChI:InChI=1/C6H5BrFN/c7-4-1-2-5(8)6(9)3-4/h1-3H,9H2

Upstream product

• 1493-27-2 ortho-nitrofluorobenzene 
• 63213-03-6 1,2-bis(3-bromophenyl)diazene 
• 364-73-8 4-Bromo-1-fluoro-2-nitrobenzene 
• 364-76-1 4-Fluoro-3-nitroaniline 

Downstream Products

• 86156-96-9 4-amino-2-bromo-5-fluorobenzenesulfonic acid 
• 627871-08-3 (5-bromo-2-fluorophenyl)hydrazine 
• 710348-24-6 N-(5-bromo-2-fluorophenyl)methanesulfonamide 
• 474710-06-0 benzhydrylidene-(5-bromo-2-fluorophenyl)-amine 
• 88288-12-4 N-(5-bromo-2-fluorophenyl)acetamide 
• 116272-41-4 4-bromo-1-fluoro-2-iodobenzene 
• 71216-20-1 5-bromo-1,3-benzothiazole-2-thiol 
• 1065169-38-1 4-(5-bromo-2-fluorophenyl)morpholine 
• 214209-96-8 5-bromo-2-fluorobenzenesulfonamide 
• 1374298-69-7 5-cyclopropyl-2-fluoroaniline 

Relevant articles and documents

Anion ligand promoted selective C-F bond reductive elimination enables C(sp2)-H fluorination

A detailed mechanism study on the anion ligand promoted selective C-H bond fluorination is reported. The role of the anion ligand has been clarified by experimental evidence and DFT calculations. Moreover, the nitrate promoted C-F bond reductive elimination enabled a selective C-H bond fluorination of various symmetric and asymmetric azobenzenes to access diverse o-fluoroanilines.

A 3-amino-4-fluorophenylboronic acid synthesis method

The invention discloses a synthetic method for 3-amino-4-fluorophenylboronic acid. The method includes the steps of conducting bromination on o-fluoronitrobenzene, conducting reduction to generate 5-bromo-2-fluoroanil, making 5-bromo-2-fluoroanil and tetrahydroxydiboron react in a coupled mode to generate the product, namely, 3-amino-4-fluorophenylboronic acid. According to the method, raw materials can be easily obtained, and operation is easy and convenient. The method is an appropriate route for preparing 3-amino-4-fluorophenylboronic acid.

CYCLOPROPANECARBOXAMIDO-SUBSTITUTE AROMATIC COMPOUNDS AS ANTI-TUMOR AGENTS

Provided are cyclopropanecarboxamido-substituted aromatic compounds that inhibit protein kinases and their use in anti-tumor area. In particular, tyrosine-kinase inhibitors and Raf-kinase inhibitors as anti-tumor agents, their preparation, pharmaceutical composition, and their use in the treatment of cancer are also provided.