(S)-2-(4-(1-(tert-butoxycarbonyl)piperidin-3-yl)phenyl)-2H-indazole-7-carboxylicacid

Base Information

Chemical Name:(S)-2-(4-(1-(tert-butoxycarbonyl)piperidin-3-yl)phenyl)-2H-indazole-7-carboxylicacid
CAS No.:1038916-08-3
Molecular Formula:C24H27N3O4
Molecular Weight:421.496
Hs Code.:
Mol file:1038916-08-3.mol

Synonyms:(S)-2-(4-(1-(tert-butoxycarbonyl)piperidin-3-yl)phenyl)-2H-indazole-7-carboxylicacid;2-{4-[(3S)-1-(tert-butoxycarbonyl)piperidin-3-yl]phenyl}-2H-indazole-7-carboxylic acid

Suppliers and Price of (S)-2-(4-(1-(tert-butoxycarbonyl)piperidin-3-yl)phenyl)-2H-indazole-7-carboxylicacid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (S)-2-(4-(1-(tert-butoxycarbonyl)piperidin-3-yl)phenyl)-2H-indazole-7-carboxylicacid

Chemical Property:

PSA：84.66000
LogP:4.77610

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (S)-2-(4-(1-(tert-butoxycarbonyl)piperidin-3-yl)phenyl)-2H-indazole-7-carboxylicacid

There total 29 articles about (S)-2-(4-(1-(tert-butoxycarbonyl)piperidin-3-yl)phenyl)-2H-indazole-7-carboxylicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1196713-67-3
2-[4-((3S)-(tertbutoxycarbonyl)piperidin-3-yl)phenyl]-2H-indazole-7-carboxylic acid methyl ester

: 1038916-08-3
2-{4-[(3S)-1-(tert-butoxycarbonyl)piperidin-3-yl]phenyl}-2H-indazole-7-carboxylic acid

Guidance literature:: With water; sodium hydroxide; In methanol; at 35 ℃; for 4h;

Reference yield:

: 1038916-05-0
tert-butyl (3S)-3-[4-({(1E)-[3-(methoxycarbonyl)-2-nitrophenyl]methylene}amino)phenyl]piperidine-1-carboxylate

: 1038916-08-3
2-{4-[(3S)-1-(tert-butoxycarbonyl)piperidin-3-yl]phenyl}-2H-indazole-7-carboxylic acid

Guidance literature:: tert-butyl (3S)-3-[4-({(1E)-[3-(methoxycarbonyl)-2-nitrophenyl]methylene}amino)phenyl]piperidine-1-carboxylate; With 2,6-dimethylpyridine; sodium azide; In N,N-dimethyl-formamide; at 110 ℃; for 20h;

With sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; at 35 ℃; for 20h;

With hydrogenchloride; water; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 138229-59-1
3-formyl-2-nitrobenzoic acid methyl ester

: 1038916-08-3
2-{4-[(3S)-1-(tert-butoxycarbonyl)piperidin-3-yl]phenyl}-2H-indazole-7-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tert-butyl methyl ether / 60 °C

2: sodium azide / N,N-dimethyl-formamide / 72 h / 90 °C

With sodium azide; In tert-butyl methyl ether; N,N-dimethyl-formamide;
DOI:10.1021/op2000783