3-(4-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 3-(4-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 875798-79-1
• Molecular Formula: C16H24N2O2
• Molecular Weight: 276.379
• Hs Code.: 2933399090
• Mol file: 875798-79-1.mol

Synonyms:TERT-BUTYL 3-(4-AMINOPHENYL)PIPERIDINE-1-CARBOXYLATE;N-BOC-3-(4-AMINOPHENYL) PIPERIDINE;

Chemical Property of 3-(4-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 412.737°C at 760 mmHg
• PKA: 4.96±0.10(Predicted)
• Flash Point: 203.417°C
• PSA: 55.56000
• Density: 1.1g/cm³
• LogP: 3.90240
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl3-(4-Aminophenyl)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 14 articles about 3-(4-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyldicarbonate (34619-03-9) + 3-(4-aminophenyl)piperidine (19733-56-3) → 3-(4-aminophenyl)piperidine-1-carboxylic acid tert-butyl ester (875798-79-1)

Guidance literature:

In dichloromethane; at 0 - 5 ℃; for 0.5h; Large scale reaction;

DOI:10.1021/op2000783

Reference yield: 53.0%

3-(4'-nitrophenyl)pyridine (4282-46-6) + di-tert-butyl dicarbonate (24424-99-5) → 3-(4-aminophenyl)piperidine-1-carboxylic acid tert-butyl ester (875798-79-1)

Guidance literature:

3-(4'-nitrophenyl)pyridine; With hydrogenchloride; platinum(IV) oxide; hydrogen; In methanol; water; for 48h; under 2068.65 Torr;

di-tert-butyl dicarbonate; With triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

3-(4-nitrophenyl)piperidine-1-carboxylic acid tert-butyl ester → 3-(4-aminophenyl)piperidine-1-carboxylic acid tert-butyl ester (875798-79-1)

Guidance literature:

With tin(ll) chloride; In water; N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

3-(4'-nitrophenyl)pyridine

tert-butyldicarbonate

3-(4-aminophenyl)piperidine

3-pyridylboronic acid

Downstream raw materials:

tert-butyl 3-[4-({[3-(methoxycarbonyl)-2-nitrophenyl]methylene}amino)phenyl]piperidine-1-carboxylate

(3S)-3-[4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl]piperidinium chloride

2-[4-((3S)-(tertbutoxycarbonyl)piperidin-3-yl)phenyl]-2H-indazole-7-carboxylic acid methyl ester

tert-butyl (3S)-3-{4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl}piperidine-1-carboxylate

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