Ethyl 2-(2,5-difluorophenyl)acetate

Base Information

• Chemical Name: Ethyl 2-(2,5-difluorophenyl)acetate
• CAS No.: 662138-60-5
• Molecular Formula: C10H10F2O2
• Molecular Weight: 200.185
• Hs Code.: 2916399090
• DSSTox Substance ID: DTXSID00381689
• Wikidata: Q82172677
• Mol file: 662138-60-5.mol

Synonyms:ethyl 2-(2,5-difluorophenyl)acetate;662138-60-5;Ethyl (2,5-Difluorophenyl)acetate;SCHEMBL13576768;DTXSID00381689;Ethyl(2,5-Difluorophenyl)acetate;MFCD02089806;AKOS009157411;TS-00333;(2,5-Difluorophenyl)acetic acid ethyl ester;CS-0322704

Chemical Property of Ethyl 2-(2,5-difluorophenyl)acetate

Chemical Property:

• Boiling Point: 224.4±25.0 °C(Predicted)
• PSA: 26.30000
• Density: 1 +-.0.06 g/cm3(Predicted)
• LogP: 2.07040
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 200.06488588
• Heavy Atom Count: 14
• Complexity: 197

Purity/Quality:

99% ^*data from raw suppliers

(2,5-Difluorophenyl)aceticacidethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CC1=C(C=CC(=C1)F)F

Technology Process of Ethyl 2-(2,5-difluorophenyl)acetate

There total 2 articles about Ethyl 2-(2,5-difluorophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethanol (64-17-5) + 2,5-difluorophenylacetic acid (85068-27-5) → ethyl 2-(2,5-difluorophenyl)acetate (662138-60-5)

Guidance literature:

With sulfuric acid; Heating;

DOI:10.1021/jm00078a014

Reference yield: 83.0%

→ ethyl 2-(2,5-difluorophenyl)acetate (662138-60-5)

Guidance literature:

Reference yield: 80.0%

ethyl 2-(2,5-difluorophenyl)acetate (662138-60-5) → 2-(2,5-difluorophenyl)ethanol (862255-56-9)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 0.5h;

upstream raw materials:

ethanol

2,5-difluorophenylacetic acid

Downstream raw materials:

ethyl α-bromo-2,5-difluorophenylacetate

3-<<4-phenyl>methyl>-5,7-dimethyl-2-ethyl-3H-imidazo<4,5-b>pyridine

3-<<4-phenyl>methyl>-5,7-dimethyl-2-ethyl-3H-imidazo<4,5-b>pyridine

3-<<4-phenyl>methyl>-5,7-dimethyl-2-ethyl-3H-imidazo<4,5-b>pyridine