Losartan N2-Glucuronide

Base Information

• Chemical Name: Losartan N2-Glucuronide
• CAS No.: 138584-35-7
• Molecular Formula: C₂₈H₃₁ClN₆O₇
• Molecular Weight: 599.043
• Mol file: 138584-35-7.mol

Synonyms:Losartan N2-Glucuronide;Losartan 2-glucuronide;1-[5-[4'-[[2-Butyl-4-chloro-5-(hydroxyMethyl)-1H-iMidazol-1-yl]Methyl][1,1'-biphenyl]-2-yl]-2H-tetrazol-2-yl]-1-deoxy-β-D-Glucopyranuronic Acid;Losartan N2-Glucuronide (90%)

Chemical Property of Losartan N2-Glucuronide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 911.509°C at 760 mmHg
• Flash Point: 505.063°C
• PSA: 188.87000
• Density: 1.581g/cm³
• LogP: 1.80490
• Storage Temp.: -20°C Freezer
• Solubility.: Methanol (Slightly), Water (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

Losartan N2-Glucuronide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of Losartan (L470500).

Technology Process of Losartan N2-Glucuronide

There total 2 articles about Losartan N2-Glucuronide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

lorsartan (114798-26-4) → losartan N1-glucuronide (138584-34-6) + losartan N2-glucuronide (138584-35-7)

Guidance literature:

With phosphate buffer; recombinant human UDP-glucuronosyltransferase 1A₁; In dimethyl sulfoxide; at 37 ℃; for 4h; pH=7.4; Further Variations:; Catalysts; Enzyme kinetics;

DOI:10.1016/j.bcp.2008.07.006

Reference yield:

lorsartan (114798-26-4) → losartan N1-glucuronide (138584-34-6) + losartan O-glucuronide (138613-25-9) + losartan N2-glucuronide (138584-35-7)

Guidance literature:

With human liver microsomes; In dimethyl sulfoxide; at 37 ℃; for 4h; pH=7.4; Further Variations:; Reagents; Enzyme kinetics;

DOI:10.1016/j.bcp.2008.07.006

upstream raw materials:

lorsartan

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