1,2,3,4-Tetrahydro-6,7-diMethoxy-1-[(3,4,5-triMethoxyphenyl)Methyl]isoquinoline

Base Information

• Chemical Name: 1,2,3,4-Tetrahydro-6,7-diMethoxy-1-[(3,4,5-triMethoxyphenyl)Methyl]isoquinoline
• CAS No.: 7668-88-4
• Molecular Formula: C21H27NO5
• Molecular Weight: 373.44278
• Mol file: 7668-88-4.mol

Synonyms:1,2,3,4-Tetrahydro-6,7-diMethoxy-1-[(3,4,5-triMethoxyphenyl)Methyl]isoquinoline;6,7-Dimethoxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

Chemical Property of 1,2,3,4-Tetrahydro-6,7-diMethoxy-1-[(3,4,5-triMethoxyphenyl)Methyl]isoquinoline

Chemical Property:

• PSA: 58.18000
• LogP: 4.28990

Purity/Quality:

99% ^*data from raw suppliers

1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-1-[(3,4,5-TRIMETHOXYPHENYL)METHYL]ISOQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3,4-Tetrahydro-6,7-diMethoxy-1-[(3,4,5-triMethoxyphenyl)Methyl]isoquinoline

There total 4 articles about 1,2,3,4-Tetrahydro-6,7-diMethoxy-1-[(3,4,5-triMethoxyphenyl)Methyl]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-(3',4',5'-trimethoxybenzyl)-3,4-dihydro-6,7-dimethoxyisoquinoline (61349-11-9) → rac-6,7-dimethoxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride (7668-88-4)

Guidance literature:

With sodium tetrahydroborate; for 19h; Ambient temperature;

Reference yield:

3,4,5-trimethoxyphenyl acetic acid (951-82-6) → rac-6,7-dimethoxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride (7668-88-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / 2 h / 190 - 210 °C

2: phosphoryl chloride / toluene / 3 h / Heating

3: 97 percent / sodium borohydride / 19 h / Ambient temperature

With sodium tetrahydroborate; trichlorophosphate; In toluene;

Reference yield:

N-β-(3,4-dimethoxyphenethyl)-3',4',5'-trimethoxyphenylacetamide (7668-87-3) → rac-6,7-dimethoxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride (7668-88-4)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphoryl chloride / toluene / 3 h / Heating

2: 97 percent / sodium borohydride / 19 h / Ambient temperature

With sodium tetrahydroborate; trichlorophosphate; In toluene;

upstream raw materials:

1-(3',4',5'-trimethoxybenzyl)-3,4-dihydro-6,7-dimethoxyisoquinoline

3,4,5-trimethoxyphenyl acetic acid

N-β-(3,4-dimethoxyphenethyl)-3',4',5'-trimethoxyphenylacetamide

2-(3,4-dimethoxyphenyl)-ethylamine

Downstream raw materials:

3-[6,7-Dimethoxy-1-(3,4,5-trimethoxy-benzyl)-3,4-dihydro-1H-isoquinolin-2-yl]-propionic acid 2-{3-[6,7-dimethoxy-1-(3,4,5-trimethoxy-benzyl)-3,4-dihydro-1H-isoquinolin-2-yl]-propionyloxy}-ethyl ester; compound with oxalic acid