61349-11-9Relevant articles and documents
Preparation method of neuromuscular blocking agent intermediate
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Paragraph 0037-058, (2018/07/30)
The invention relates to a preparation method of a neuromuscular blocking agent intermediate. The method includes: a compound as shown in formula (II) and a cyclization reagent are allowed to have reaction in a reaction solvent to generate a compound as s
Two optimized synthetic pathways toward a chiral precursor of Mivacurium chloride and other skeletal muscle relaxants
Vilhanová, Beáta,Matou?ek, Václav,Václavík, Ji?í,Syslová, Kamila,P?ech, Jan,Pechá?ek, Jan,?ot, Petr,Janu??ák, Jakub,Toman, Jaromír,Zápal, Jakub,Kuzma, Marek,Ka?er, Petr
, p. 50 - 55 (2013/02/23)
A chiral precursor of Mivacurium chloride, (R)-5′-methoxylaudanosine, was prepared using two different methods. The chiral resolution of racemic 5′-methoxylaudanosine, typically used in industry, was carried out in parallel with a procedure consisting of
Synthesis of 8-oxoberbines and related benzolactams by Pd(OAc) 2-catalyzed direct aromatic carbonylation
Miyazawa, Mamoru,Tokuhashi, Takashi,Horibata, Akiyoshi,Nakamura, Takatoshi,Onozaki, Yu,Kurono, Nobuhito,Senboku, Hisanori,Tokuda, Masao,Ohkuma, Takeshi,Orito, Kazuhiko
, p. E48-E54 (2013/06/05)
A variety of alkoxy-substituted benzolactams with a berbine or yohimbane skeleton were prepared from 1-benzyl-1,2,3,4-tetrahydroisoquinolines or 1-benzyl-1,2,3,4-tetrahydro-β-carbolines by a phosphine-free Pd(II)-catalyzed direct aromatic carbonylation in a Pd(OAc)2-Cu(OAc) 2 catalytic system. The site selectivity was compared with that of the carbonylation with Pd(OAc)2 or Pd(OAc)2·2 PPh3, respectively.