A 395

Base Information

Chemical Name:A 395
CAS No.:2089148-72-9
Molecular Formula:C₂₆H₃₅FN₄O₂S
Molecular Weight:486.654
Hs Code.:

Synonyms:3-Pyrrolidinamine, 1-(7-fluoro-2,3-dihydro-1H-inden-1-yl)-N,N-dimethyl-4-[4-[4-(methylsulfonyl)-1-piperazinyl]phenyl]-, (3R,4S)-;;

Suppliers and Price of A 395

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
A395 >98%
1 g
$ 3500.00

DC Chemicals
A395 >98%
250 mg
$ 1750.00

DC Chemicals
A395 >98%
100 mg
$ 950.00

ChemScene
A-395 99.31%
25mg
$ 450.00

ChemScene
A-395 99.31%
10mg
$ 190.00

ChemScene
A-395 99.31%
5mg
$ 110.00

Total 5 raw suppliers

Chemical Property of A 395

Chemical Property:

Boiling Point:612.2±65.0 °C(Predicted)
Density:1.30±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

A395 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of A 395

There total 4 articles about A 395 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3R,4S)-N,N-dimethyl-4-(4-(4-(methylsulfonyl)piperazin-1-yl)phenyl)pyrrolidin-3-amine

: 651735-59-0
7-fluoro-2,3-dihydro-1H-inden-1-one

: 2089148-72-9
(3R,4S)-1-(7-fluoro-2,3-dihydro-1H-inden-1-yl)-4-{4-[4-(methanesulfonyl)piperazin-1-yl]phenyl}-N,N-dimethylpyrrolidin-3-amine

Guidance literature:: With sodium cyanoborohydride; In methanol; at 50 ℃; for 60h; pH=4;
DOI:10.1016/j.bmcl.2017.02.030

Reference yield:

: (3R,4S)-1-benzyl-4-(4-bromophenyl)-N,N-dimethylpyrrolidin-3-amine

: 2089148-72-9
(3R,4S)-1-(7-fluoro-2,3-dihydro-1H-inden-1-yl)-4-{4-[4-(methanesulfonyl)piperazin-1-yl]phenyl}-N,N-dimethylpyrrolidin-3-amine

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; sodium t-butanolate / 1,4-dioxane / 2 h / 110 °C

2: 20% palladium hydroxide-activated charcoal / 2,2,2-trifluoroethanol / 4 h / 20 °C / 1551.49 Torr

3: sodium cyanoborohydride / methanol / 60 h / 50 °C / pH 4

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 20% palladium hydroxide-activated charcoal; sodium cyanoborohydride; sodium t-butanolate; XPhos; In 1,4-dioxane; methanol; 2,2,2-trifluoroethanol;
DOI:10.1016/j.bmcl.2017.02.030

Reference yield:

: (3R,4S)-1-benzyl-N,N-dimethyl-4-(4-(4-(methylsulfonyl)piperazin-1-yl)phenyl)pyrrolidin-3-amine

: 2089148-72-9
(3R,4S)-1-(7-fluoro-2,3-dihydro-1H-inden-1-yl)-4-{4-[4-(methanesulfonyl)piperazin-1-yl]phenyl}-N,N-dimethylpyrrolidin-3-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 20% palladium hydroxide-activated charcoal / 2,2,2-trifluoroethanol / 4 h / 20 °C / 1551.49 Torr

2: sodium cyanoborohydride / methanol / 60 h / 50 °C / pH 4

With 20% palladium hydroxide-activated charcoal; sodium cyanoborohydride; In methanol; 2,2,2-trifluoroethanol;
DOI:10.1016/j.bmcl.2017.02.030