651735-59-0

Usage

Uses

Used in Pharmaceutical Synthesis:
7-Fluoro-1-indanone is utilized as an intermediate in the synthesis of a range of pharmaceuticals. Its unique structure and reactivity make it a valuable component in the development of new drugs.
Used in Agrochemical Production:
In the agrochemical industry, 7-Fluoro-1-indanone serves as an intermediate for the production of various agrochemicals, contributing to the creation of compounds that can enhance crop protection and yield.
Used in Organic Synthesis:
7-Fluoro-1-indanone is employed as a versatile building block in organic synthesis across different chemical industries. Its capacity to engage in multiple types of chemical reactions allows for the construction of a wide array of organic compounds.
Used in Medicinal Chemistry and Drug Discovery:
7-Fluoro-1-indanone holds potential in medicinal chemistry and drug discovery, where it is leveraged as a key structural motif. Its presence in the design of bioactive compounds aids in the exploration of new therapeutic agents and pharmaceutical leads.

InChI:InChI=1/C9H7FO/c10-7-3-1-2-6-4-5-8(11)9(6)7/h1-3H,4-5H2

Upstream product

• 898767-04-9 3-chloro-1-(2-fluorophenyl)propan-1-one 
• 58161-36-7 N-(3-oxo-2,3-dihydro-1H-inden-4-yl)acetamide 
• 32202-61-2 4-aminoindan 
• 77802-37-0 N-(2,3-dihydro-1H-inden-4-yl)acetamide 
• 393-52-2 2-Fluorobenzoyl chloride 
• 628732-03-6 7-amino-2,3-dihydro-1H-inden-1-one 
• 445-29-4 o-fluoro-benzoic acid 
• 50-00-0 formaldehyd 
• 108-59-8 malonic acid dimethyl ester 
• 71095-56-2 1-(2-bromophenyl)-2-propen-1-one 
• 2142-69-0 2-bromophenyl methyl ketone 
• 74-85-1 ethene 

Downstream Products

• 2089148-72-9 (3R,4S)-1-(7-fluoro-2,3-dihydro-1H-inden-1-yl)-4-{4-[4-(methanesulfonyl)piperazin-1-yl]phenyl}-N,N-dimethylpyrrolidin-3-amine 
• 1092347-71-1 7-fluoro-4-nitro-2,3-dihydro-1H-inden-1-one 
• 2260959-50-8 7-fluoro-4-nitro-2,3-dihydro-1H-inden-1-ol 
• 2260959-52-0 7-fluoro-2,3-dihydro-1H-inden-4-amine 

Relevant academic research and scientific papers

Rh-Catalyzed Annulation of Benzoic Acids, Formaldehyde, and Malonates via ortho-Hydroarylation to Indanones

A three-component reaction from readily available low-cost materials of benzoic acids, formaldehyde, and malonates for the preparation of indanones by rhodium catalysis is reported. The annulation is initiated by an ortho-hydroarylation of benzoic acids, and a Lewis acid is not required. The solvent has a significant influence to the reaction, and 2-substituted or nonsubstituted indanones are obtained by the change of solvent.

Novel synthetic method for 7-halogen-1-indanone

The invention discloses a novel synthetic method for 7-halogen-1-indanone. The reaction general formula of the method is shown in the description, wherein X is fluorine, chlorine or bromine. The method provided by the invention uses o-halogenated acetophenone as a starting raw material, an iron-catalyzed carbonyl methylenation reaction is performed to obtain a vinyl ketone, and acid-catalyzed ringclosure is performed to obtain the 7-halogen-1-indanone. The method provided by the invention has the advantages that the raw materials are simple and easy to obtain, the post-treatment is simple andthe total yield is high, and can provide an important reference for industrialized production.

CARBAMATE DERIVATIVE COMPOUNDS, PROCESSES FOR PREPARING THEM AND THEIR USES

The present invention relates to a pharmaceutical composition for treating or preventing CNS disorders containing a carbamate derivative compound and/or pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the present invention relates to a method for treatment or prevention CNS disorders comprising administering a carbamate derivative compound in a pharmaceutically effective amount to a subject in need of treatment or prevention of CNS disorders.

SPIROCYCLIC HAT INHIBITORS AND METHODS FOR THEIR USE

Compounds having a structure of Formula (IX) or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b, Q1----Q2, R6, R7, A, B, W, x, and y are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.

NOVEL COMPOUND, AND KINESIN SPINDLE PROTEIN INHIBITOR AND APPLICATION THEREOF

A compound represented by the following General Formula (I): where, in General Formula (I), R1 and R2 each represent an alkyl group which may have a substituent, R3 represents the following General Formula (II) or (III), and R1 and R2 may be identical or different, where, in General Formulas (II) and (III), X represents a hydrogen atom or a halogen atom, R4 represents a methyl group, a dimethyl group or an oxygen atom, and * represents a binding position.

COMPOUND, KINESIN SPINDLE PROTEIN INHIBITOR, AND APPLICATION THEREOF

A compound represented by the following General Formula (I): where, in General Formula (I), R1 and R2 each represent an alkyl group which may have a substituent, R3 represents the following General Formula (II) or (III), and R1 and R2 may be identical or different, where, in General Formulas (II) and (III), X represents a hydrogen atom or a halogen atom, R4 represents a methyl group, a dimethyl group or an oxygen atom, and * represents a binding position.

THERAPEUTIC FLUOROETHYLCYANO GUANIDINES

Disclosed herein is compound having a formula as described herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.

SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS

Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.

A Convenient Synthesis of 7-Halo-1-indanones and 8-Halo-1-tetralones

A regioselective oxidation of N-indan-4-yl-acetamide or N-(5,6,7,8-tetrahydronaphthalen-1-yl)acetamide with potassium permanganate followed by acidic hydrolysis gave 7-aminoindan-1-one or 8-aminotetral-1-one in good yield. The amino ketones were converted to the corresponding 7-haloindanone or the 8-halotetralone. Another method to prepare 7-haloindan-1-ones was completed by a cyclization of 3-chloro-1-(2-halophenyl)propan-1-one under Friedel-Crafts conditions to produce the product in gram quantity.