(R)-3-(2-(bis(3-fluorophenyl)(hydroxy)methyl)pyrrolidin-1-ylsulfonyl)propan-1-ol

Base Information

Chemical Name:(R)-3-(2-(bis(3-fluorophenyl)(hydroxy)methyl)pyrrolidin-1-ylsulfonyl)propan-1-ol
CAS No.:1370293-29-0
Molecular Formula:C₂₀H₂₃F₂NO₄S
Molecular Weight:411.47
Hs Code.:

Synonyms:(R)-3-(2-(bis(3-fluorophenyl)(hydroxy)methyl)pyrrolidin-1-ylsulfonyl)propan-1-ol

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Chemical Property of (R)-3-(2-(bis(3-fluorophenyl)(hydroxy)methyl)pyrrolidin-1-ylsulfonyl)propan-1-ol

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Technology Process of (R)-3-(2-(bis(3-fluorophenyl)(hydroxy)methyl)pyrrolidin-1-ylsulfonyl)propan-1-ol

There total 5 articles about (R)-3-(2-(bis(3-fluorophenyl)(hydroxy)methyl)pyrrolidin-1-ylsulfonyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1370293-23-4
(R)-3-(2-(hydroxydiphenylmethyl)pyrrolidin-1-ylsulfonyl)propyl acetate

: 1370293-29-0
(R)-3-(2-(bis(3-fluorophenyl)(hydroxy)methyl)pyrrolidin-1-ylsulfonyl)propan-1-ol

Guidance literature:: With methylamine; In methanol; at 20 ℃; for 1h;
DOI:10.1021/jm201627n

Reference yield:

: 1204659-63-1
(S)-bis(3-fluorophenyl)(pyrrolidin-2-yl)methanol

: 1370293-29-0
(R)-3-(2-(bis(3-fluorophenyl)(hydroxy)methyl)pyrrolidin-1-ylsulfonyl)propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

2: sodium iodide / N,N-dimethyl-formamide / 12 h / 90 °C

3: methylamine / methanol / 1 h / 20 °C

With triethylamine; methylamine; sodium iodide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm201627n

Reference yield:

: 1370293-17-6
(R)-(1-(3-chloropropylsulfonyl)pyrrolidin-2-yl)bis(3-fluorophenyl)methanol

: 1370293-29-0
(R)-3-(2-(bis(3-fluorophenyl)(hydroxy)methyl)pyrrolidin-1-ylsulfonyl)propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium iodide / N,N-dimethyl-formamide / 12 h / 90 °C

2: methylamine / methanol / 1 h / 20 °C

With methylamine; sodium iodide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm201627n