Technology Process of 7-chloro-3-cyclohexyl-1-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2-phenyl-1H-indole-6-carboxylic acid, methyl ester
There total 7 articles about 7-chloro-3-cyclohexyl-1-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2-phenyl-1H-indole-6-carboxylic acid, methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
7-chloro-3-cyclohexyl-2-phenyl-1H-indole-6-carboxylic acid;
With
sodium hydride;
In
dimethyl sulfoxide;
at 20 ℃;
for 0.166667h;
2-(tert-butyldimethylsilyloxy)ethyl bromide;
With
potassium iodide;
In
dimethyl sulfoxide;
at 20 ℃;
for 19h;
With
hydrogenchloride; water;
In
dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium methylate / methanol / 23 h / 20 - 60 °C / Heating / reflux
1.2: 20 °C
2.1: hydrogen / 20% Pd(OH)2 on carbon / tetrahydrofuran; methanol / 27 h / 20 °C
3.1: methanol; hexane; benzene / 2.25 h / 0 - 20 °C
3.2: 0.25 h
4.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 2 h / 20 °C
5.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium(0) / ethanol; water; toluene / 20 - 60 °C
6.1: sodium hydride / dimethyl sulfoxide / 0.17 h / 20 °C
6.2: 19 h / 20 °C
With
hydrogen; sodium methylate; pyridinium hydrobromide perbromide; sodium hydride; sodium carbonate; lithium chloride;
tetrakis(triphenylphosphine) palladium(0); 20% Pd(OH)2 on carbon;
In
tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; toluene; benzene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium methylate / methanol / 23 h / 20 - 60 °C / Heating / reflux
1.2: 20 °C
2.1: hydrogen / 20% Pd(OH)2 on carbon / tetrahydrofuran; methanol / 27 h / 20 °C
3.1: methanol; hexane; benzene / 2.25 h / 0 - 20 °C
3.2: 0.25 h
4.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 2 h / 20 °C
5.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium(0) / ethanol; water; toluene / 20 - 60 °C
6.1: sodium hydride / dimethyl sulfoxide / 0.17 h / 20 °C
6.2: 19 h / 20 °C
With
hydrogen; sodium methylate; pyridinium hydrobromide perbromide; sodium hydride; sodium carbonate; lithium chloride;
tetrakis(triphenylphosphine) palladium(0); 20% Pd(OH)2 on carbon;
In
tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; toluene; benzene;
