(2E)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid

Base Information

• Chemical Name: (2E)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid
• CAS No.: 1055320-88-1
• Molecular Formula: C₃₈H₃₉N₃O₅
• Molecular Weight: 617.745

Synonyms:(2E)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid

Chemical Property of (2E)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (2E)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid

There total 12 articles about (2E)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2E)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid, ethyl ester (1055320-87-0) → (2E)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid (1055320-88-1) + (2Z)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid (1055321-05-5)

Guidance literature:

(2E)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid, ethyl ester; With potassium trimethylsilonate; In tetrahydrofuran; at 20 ℃; for 19.25h;

With hydrogenchloride; water; In tetrahydrofuran;

Reference yield:

7-chloro-1H-indole-6-carboxylic acid (1055320-72-3) → (2E)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid (1055320-88-1) + (2Z)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid (1055321-05-5)

Guidance literature:

Multi-step reaction with 10 steps

1.1: sodium methylate / methanol / 23 h / 20 - 60 °C / Heating / reflux

1.2: 20 °C

2.1: hydrogen / 20% Pd(OH)2 on carbon / tetrahydrofuran; methanol / 27 h / 20 °C

3.1: methanol; hexane; benzene / 2.25 h / 0 - 20 °C

3.2: 0.25 h

4.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 2 h / 20 °C

5.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 20 - 60 °C

6.1: sodium hydride / dimethyl sulfoxide / 0.17 h / 20 °C

6.2: 19 h / 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

8.1: sodium hydride / dimethyl sulfoxide / 0.33 h / 20 - 200 °C / Microwave irradiation

9.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 20 °C

10.1: potassium trimethylsilonate / tetrahydrofuran / 19.25 h / 20 °C

With potassium trimethylsilonate; tetrabutyl ammonium fluoride; hydrogen; sodium methylate; pyridinium hydrobromide perbromide; sodium hydride; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 20% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; benzene;

Reference yield:

7-chloro-3-cyclohexenyl-1H-indole-6-carboxylic acid (1055320-73-4) → (2E)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid (1055320-88-1) + (2Z)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid (1055321-05-5)

Guidance literature:

Multi-step reaction with 9 steps

1.1: hydrogen / 20% Pd(OH)2 on carbon / tetrahydrofuran; methanol / 27 h / 20 °C

2.1: methanol; hexane; benzene / 2.25 h / 0 - 20 °C

2.2: 0.25 h

3.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 2 h / 20 °C

4.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 20 - 60 °C

5.1: sodium hydride / dimethyl sulfoxide / 0.17 h / 20 °C

5.2: 19 h / 20 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

7.1: sodium hydride / dimethyl sulfoxide / 0.33 h / 20 - 200 °C / Microwave irradiation

8.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 20 °C

9.1: potassium trimethylsilonate / tetrahydrofuran / 19.25 h / 20 °C

With potassium trimethylsilonate; tetrabutyl ammonium fluoride; hydrogen; pyridinium hydrobromide perbromide; sodium hydride; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 20% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; benzene;

upstream raw materials:

(2E)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid, ethyl ester

7-chloro-1H-indole-6-carboxylic acid

6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indole-9-carboxylic acid

methyl 7-chloro-3-cyclohexyl-1H-indole-6-carboxylate

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