Technology Process of 2,4-diaminoquinazolin-6-yl 2,5-dimethoxybenzoate
There total 5 articles about 2,4-diaminoquinazolin-6-yl 2,5-dimethoxybenzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: N,N-dimethyl-formamide / 10 h / 145 °C
2: hydrogen / palladium over charcoal / methanol / 8 h
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C
With
hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
palladium over charcoal;
In
methanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: boron tribromide / dichloromethane / 48 h / 0 - 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C
2.2: 6 h / 20 °C
3.1: N,N-dimethyl-formamide / 10 h / 145 °C
4.1: hydrogen / palladium over charcoal / methanol / 8 h
5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C
With
hydrogen; boron tribromide; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
palladium over charcoal;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
