127667-01-0

Basic information

• Product Name: 2-FLUORO-5-METHOXYBENZONITRILE
• Synonyms: 2-FLUORO-5-METHOXYBENZONITRILE;BUTTPARK 80\01-21;Fluoromethoxybenzonitrile2;2-Fluoro-5-methyloxybenzonitrile;2-Fluoro-5-methoxybenzonitrile98%;6-Fluoro-m-anisonitrile;3-Cyano-4-fluoroanisole;3-Cyano-4-fluoroanisole, 6-Fluoro-m-anisonitrile
• CAS NO: 127667-01-0
• Molecular Formula: C₈H₆FNO
• Molecular Weight: 151.14
• Product Categories: Aromatic Nitriles;Nitrile;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds;Nitriles;Fluorine series
• Mol File: 127667-01-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 77-80°C
• Boiling Point: 232.7 °C at 760 mmHg
• Flash Point: 94.5 °C
• Appearance: /
• Density: 1.18 g/cm³
• Vapor Pressure: 0.0582mmHg at 25°C
• Refractive Index: 1.505
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• CAS DataBase Reference: 2-FLUORO-5-METHOXYBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-5-METHOXYBENZONITRILE(127667-01-0)
• EPA Substance Registry System: 2-FLUORO-5-METHOXYBENZONITRILE(127667-01-0)

Safety Data

• Hazard Codes: T
• Statements: 20/21/22-36/37/38-36/38
• Safety Statements: 26-36/37/39-45-36/37
• RIDADR: 3439
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 127667-01-0(Hazardous Substances Data)

Usage

General Description

2-Fluoro-5-methoxybenzonitrile is a chemical compound with the molecular formula C8H6FNO. It is a nitrile compound with a fluorine atom and a methoxy group attached to a benzene ring. This chemical is commonly used in the synthesis of pharmaceuticals and agrochemicals. It may also be used as a building block for the creation of other complex organic compounds. Due to its potential applications in various industries, 2-fluoro-5-methoxybenzonitrile is a valuable intermediate in organic synthesis.

InChI:InChI=1/C8H6FNO/c1-11-7-2-3-8(9)6(4-7)5-10/h2-4H,1H3

Upstream product

• 459-60-9 1-fluoro-4-methoxybenzene 
• 105728-90-3 2-fluoro-5-methoxybenzaldehyde 
• 796120-91-7 2-fluoro-5-methoxybenzaldehyde oxime 
• 67-56-1 methanol 
• 179897-89-3 5-Bromo-2-fluoro-benzonitrile 
• 544-92-3 copper(I) cyanide 
• 202925-07-3 2-chloro-1-fluoro-4-methoxybenzene 

Downstream Products

• 127667-11-2 2-(Cyano-phenyl-methyl)-5-methoxy-benzonitrile 
• 800371-47-5 5-methoxy-2-(4-phenylpiperidino)benzonitrile 
• 58514-96-8 5-(methyloxy)-1H-indazol-3-amine 
• 890132-80-6 5-methoxy-2-(4-methyl-imidazol-1-yl)-benzonitrile 
• 104798-53-0 2-fluoro-5-hydroxybenzenecarbonitrile 
• 1149375-21-2 6-fluoro-3-methoxy-2-nitrobenzonitrile 
• 80272-34-0 3-(4-Fluoro-phenyl)-6-methoxy-indan-1-one 
• 116617-01-7 3-Amino-1-cyano-1-(4-fluoro-phenyl)-5-methoxy-1H-indene-2-carboxylic acid methyl ester 
• 38711-08-9 6-benzyloxy-quinazoline-2,4-diamine 
• 1092778-58-9 2,4-diaminoquinazolin-6-yl 2,5-dimethoxybenzoate 
• 1092778-83-0 5-(benzyloxy)-2-fluorobenzonitrile 
• 160664-91-5 3-nitro4-hydroxy-6-(2-fluoro-5-methoxyphenyl) pyridone 
• 160664-90-4 4-hydroxy-6-(2-fluoro-5-methoxyphenyl) pyridone 
• 400-92-0 2-fluoro-5-methoxybenzamide 

Relevant articles and documents

A substituted including monofluoro-benzene [...] preparation method of the compound (by machine translation)

The invention discloses a including monofluoro-benzene substituted [...] compound N - ((3 - (2 - fluoro - 5 - methoxyphenyl) - 1, 2, 4 - oxadiazole - 5 - yl) methyl) aminoethane preparation method, in order to 4 - fluoro anisole as the starting material,

Synthesis method of fluorobenzene substituted oxadiazole compound

The invention discloses a synthesis method of a fluorobenzene substituted oxadiazole compound N-((3-(2-fluoro-5-methoxyphenyl)-1,2,4-oxadiazole-5-yl)methyl)ethylamine. A target product 7 is obtained through hydroformylation, oximation, elimination, additi

Displacement of Halogen of 2-Halogeno-Substituted Benzonitriles with Carbanions. Preparation of (2-Cyanoaryl)arylacetonitriles

(2-Cyanoaryl)arylacetonitriles are obtained by displacement of halogen of 2-halobenzonitriles with phenylacetonitrile anions.The method also applies to a number of heteroaromatics with ortho-situated halogen and cyano groups and to heteroarylacetonitrile anions.The anions were generated by using potassium tert-butoxide or potassium carbonate.Calculated electron densities of the electrophilic centers reflect the reactivity in the displacement reaction.The calculations indicate that the potassium ion complexes with the cyano group of the 2-halobenzonitriles in nonpolar solvents, thus promoting competitive addition of the anion to the cyano group.Carbanions derived from acids with pKa ca. 19-23 similarly displaced the halogen of 2-halobenzonitriles.