ethyl {(R)-4-[2-{[(R)-2-(3-bromoisoxazol-5-yl)-2-hydroxyethyl]tert-butoxycarbonylamino}propyl]phenoxy}acetate

Base Information

• Chemical Name: ethyl {(R)-4-[2-{[(R)-2-(3-bromoisoxazol-5-yl)-2-hydroxyethyl]tert-butoxycarbonylamino}propyl]phenoxy}acetate
• CAS No.: 933055-71-1
• Molecular Formula: C₂₃H₃₁BrN₂O₇
• Molecular Weight: 527.412
• Mol file: 933055-71-1.mol

Synonyms:ethyl {(R)-4-[2-{[(R)-2-(3-bromoisoxazol-5-yl)-2-hydroxyethyl]tert-butoxycarbonylamino}propyl]phenoxy}acetate

Chemical Property of ethyl {(R)-4-[2-{[(R)-2-(3-bromoisoxazol-5-yl)-2-hydroxyethyl]tert-butoxycarbonylamino}propyl]phenoxy}acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl {(R)-4-[2-{[(R)-2-(3-bromoisoxazol-5-yl)-2-hydroxyethyl]tert-butoxycarbonylamino}propyl]phenoxy}acetate

There total 1 articles about ethyl {(R)-4-[2-{[(R)-2-(3-bromoisoxazol-5-yl)-2-hydroxyethyl]tert-butoxycarbonylamino}propyl]phenoxy}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-[(R)-2-{[(R)-2-(3-bromoisoxazol-5-yl)-2-hydroxyethyl]tert-butoxycarbonylamino}propyl]phenol + ethyl bromoacetate (105-36-2) → ethyl {(R)-4-[2-{[(R)-2-(3-bromoisoxazol-5-yl)-2-hydroxyethyl]tert-butoxycarbonylamino}propyl]phenoxy}acetate (933055-71-1)

Guidance literature:

With potassium carbonate; In acetone; for 6h; Heating;

DOI:10.1016/j.bmc.2007.01.056

Reference yield: 72.0%

ethyl {(R)-4-[2-{[(R)-2-(3-bromoisoxazol-5-yl)-2-hydroxyethyl]tert-butoxycarbonylamino}propyl]phenoxy}acetate (933055-71-1) + trifluoroacetic acid (76-05-1) → ethyl {(R)-4-[2-{[(R)-2-(3-bromoisoxazol-5-yl)-2-hydroxyethyl]amino}propyl]phenoxy}acetate trifluoroacetate

Guidance literature:

In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/j.bmc.2007.01.056

Reference yield:

ethyl {(R)-4-[2-{[(R)-2-(3-bromoisoxazol-5-yl)-2-hydroxyethyl]tert-butoxycarbonylamino}propyl]phenoxy}acetate (933055-71-1) → {(R)-4-[2-{[(R)-2-(3-bromoisoxazol-5-yl)-2-hydroxyethyl]tert-butoxycarbonylamino}propyl]phenoxy}acetic acid

Guidance literature:

With potassium carbonate; In methanol; water; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2007.01.056

upstream raw materials:

ethyl bromoacetate