N-cyclohexyl-2-(4-hydroxy-4-piperidinyl)-N-methylpropionamide

Base Information

• Chemical Name: N-cyclohexyl-2-(4-hydroxy-4-piperidinyl)-N-methylpropionamide
• CAS No.: 78021-68-8
• Molecular Formula: C₁₅H₂₈N₂O₂
• Molecular Weight: 268.4
• Mol file: 78021-68-8.mol

Synonyms:N-cyclohexyl-2-(4-hydroxy-4-piperidinyl)-N-methylpropionamide

Chemical Property of N-cyclohexyl-2-(4-hydroxy-4-piperidinyl)-N-methylpropionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-cyclohexyl-2-(4-hydroxy-4-piperidinyl)-N-methylpropionamide

There total 3 articles about N-cyclohexyl-2-(4-hydroxy-4-piperidinyl)-N-methylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-(1-benzyl-4-hydroxy-4-piperidinyl)-N-cyclohexyl-N-methylpropionamide (83604-64-2) → N-cyclohexyl-2-(4-hydroxy-4-piperidinyl)-N-methylpropionamide (78021-68-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; at 50 ℃; for 15h; under 2327.2 Torr;

DOI:10.1021/jm00355a010

Reference yield:

N-methylcyclohexylamine (100-60-7) → N-cyclohexyl-2-(4-hydroxy-4-piperidinyl)-N-methylpropionamide (78021-68-8)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CHCl₃ / 1 h / 20 °C

2: 1.) LDA / 1.) THF, hexane, -75 deg C, 20 min, 2.) THF, hexane, -75 deg C, 30 min

3: 91 percent / H₂ / 10percent Pd/C / acetic acid / 15 h / 50 °C / 2327.2 Torr

With hydrogen; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In chloroform; acetic acid;

DOI:10.1021/jm00355a010

Reference yield:

N-cyclohexyl-N-methylpropionamide (78021-83-7) → N-cyclohexyl-2-(4-hydroxy-4-piperidinyl)-N-methylpropionamide (78021-68-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, hexane, -75 deg C, 20 min, 2.) THF, hexane, -75 deg C, 30 min

2: 91 percent / H₂ / 10percent Pd/C / acetic acid / 15 h / 50 °C / 2327.2 Torr

With hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In acetic acid;

DOI:10.1021/jm00355a010

upstream raw materials:

2-(1-benzyl-4-hydroxy-4-piperidinyl)-N-cyclohexyl-N-methylpropionamide

N-methylcyclohexylamine

N-cyclohexyl-N-methylpropionamide

Downstream raw materials:

2-(1-Allyl-4-hydroxy-piperidin-4-yl)-N-cyclohexyl-N-methyl-propionamide

N-cyclohexyl-2-<1-(3-methoxyphenethyl)-4-hydroxy-4-piperidinyl>-N-methylpropionamide