(2R,3R)-(-)-3-hydroxy-3-methyl-1-(toluene-4-sulfonyl)pyrrolidine-2-carboxylic acid

Base Information

Chemical Name:(2R,3R)-(-)-3-hydroxy-3-methyl-1-(toluene-4-sulfonyl)pyrrolidine-2-carboxylic acid
CAS No.:794567-08-1
Molecular Formula:C₁₃H₁₇NO₅S
Molecular Weight:299.348
Hs Code.:

Synonyms:(2R,3R)-(-)-3-hydroxy-3-methyl-1-(toluene-4-sulfonyl)pyrrolidine-2-carboxylic acid

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Chemical Property of (2R,3R)-(-)-3-hydroxy-3-methyl-1-(toluene-4-sulfonyl)pyrrolidine-2-carboxylic acid

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Technology Process of (2R,3R)-(-)-3-hydroxy-3-methyl-1-(toluene-4-sulfonyl)pyrrolidine-2-carboxylic acid

There total 8 articles about (2R,3R)-(-)-3-hydroxy-3-methyl-1-(toluene-4-sulfonyl)pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63366-76-7
(toluene-4-sulfonylamino)acetic acid benzyl ester

: 78-94-4,25038-87-3
methyl vinyl ketone

: 794567-08-1
(2R,3R)-(-)-3-hydroxy-3-methyl-1-(toluene-4-sulfonyl)pyrrolidine-2-carboxylic acid

: 3-hydroxy-3-methyl-1-(p-tolylsulfonyl)-pyrrolidine-2-carboxylic acid

: 3-hydroxy-3-methyl-1-(p-tolylsulfonyl)-pyrrolidine-2-carboxylic acid

: (2R,3S)-3-hydroxy-3-methyl-1-(p-tolylsulfonyl)-pyrrolidine-2-carboxylic acid

Guidance literature:: (toluene-4-sulfonylamino)acetic acid benzyl ester; methyl vinyl ketone; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 23 ℃; for 14h;

With hydrogen; palladium on activated charcoal; In methanol; at 23 ℃; for 14h; under 760 Torr;

With Cinchonidin; In ethyl acetate; Title compound not separated from byproducts; Heating;
DOI:10.1246/bcsj.77.1649

Reference yield:

: 944413-16-5
4-methyl-N-(3-oxobutyl)-N-(2-oxoethyl)benzenesulfonamide

: 794567-08-1
(2R,3R)-(-)-3-hydroxy-3-methyl-1-(toluene-4-sulfonyl)pyrrolidine-2-carboxylic acid

Guidance literature:: 4-methyl-N-(3-oxobutyl)-N-(2-oxoethyl)benzenesulfonamide; In tetrahydrofuran; water; at 20 ℃; for 7.5h;

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In tetrahydrofuran; water; tert-butyl alcohol; at 20 ℃; for 3h; Further stages.;
DOI:10.1021/ol0706004