1-amino-2-(methoxycarbonyl)-4-cyano-4-(4-fluorophenyl)-3,4-dihydronaphthalene

Base Information

Chemical Name:1-amino-2-(methoxycarbonyl)-4-cyano-4-(4-fluorophenyl)-3,4-dihydronaphthalene
CAS No.:127999-79-5
Molecular Formula:C₁₉H₁₅FN₂O₂
Molecular Weight:322.339
Hs Code.:

Synonyms:1-amino-2-(methoxycarbonyl)-4-cyano-4-(4-fluorophenyl)-3,4-dihydronaphthalene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-amino-2-(methoxycarbonyl)-4-cyano-4-(4-fluorophenyl)-3,4-dihydronaphthalene

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Technology Process of 1-amino-2-(methoxycarbonyl)-4-cyano-4-(4-fluorophenyl)-3,4-dihydronaphthalene

There total 1 articles about 1-amino-2-(methoxycarbonyl)-4-cyano-4-(4-fluorophenyl)-3,4-dihydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 127999-69-3
methyl 4-cyano-4-(2-cyanophenyl)-4-(4-fluorophenyl)butanoate

: 127999-79-5
1-amino-2-(methoxycarbonyl)-4-cyano-4-(4-fluorophenyl)-3,4-dihydronaphthalene

Guidance literature:: With potassium tert-butylate; In toluene; for 1h;
DOI:10.1021/jo00303a012

Reference yield:

: 127999-79-5
1-amino-2-(methoxycarbonyl)-4-cyano-4-(4-fluorophenyl)-3,4-dihydronaphthalene

: 3345-77-5
4-(4-fluorophenyl)-3,4-dihydro-1-oxo-1(2H)-naphthalene-4-carboxylic acid

Guidance literature:: With sulfuric acid; acetic acid; Yield given. Multistep reaction; 1.) 100 deg C, 2.) 115 deg C, 18 h;
DOI:10.1021/jo00303a012

Reference yield:

: 127999-79-5
1-amino-2-(methoxycarbonyl)-4-cyano-4-(4-fluorophenyl)-3,4-dihydronaphthalene

: 79836-47-8,79560-24-0
4-(4-fluorophenyl)-3,4-dihydro-1(2H)-naphthalen-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) acetic acid, 2.) 67percent aq. sulfuric acid / 1.) 100 deg C, 2.) 115 deg C, 18 h

2: 85 percent / N-methylpyrrolidone / 15 h / 100 °C

With 1-methyl-pyrrolidin-2-one; sulfuric acid; acetic acid;
DOI:10.1021/jo00303a012