4-(4-fluorophenyl)-3,4-dihydro-1-oxo-1(2H)-naphthalene-4-carboxylic acid

Base Information

• Chemical Name: 4-(4-fluorophenyl)-3,4-dihydro-1-oxo-1(2H)-naphthalene-4-carboxylic acid
• CAS No.: 3345-77-5
• Molecular Formula: C₁₇H₁₃FO₃
• Molecular Weight: 284.287
• Mol file: 3345-77-5.mol

Synonyms:4-(4-fluorophenyl)-3,4-dihydro-1-oxo-1(2H)-naphthalene-4-carboxylic acid

Chemical Property of 4-(4-fluorophenyl)-3,4-dihydro-1-oxo-1(2H)-naphthalene-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-(4-fluorophenyl)-3,4-dihydro-1-oxo-1(2H)-naphthalene-4-carboxylic acid

There total 2 articles about 4-(4-fluorophenyl)-3,4-dihydro-1-oxo-1(2H)-naphthalene-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-amino-2-(methoxycarbonyl)-4-cyano-4-(4-fluorophenyl)-3,4-dihydronaphthalene (127999-79-5) → 4-(4-fluorophenyl)-3,4-dihydro-1-oxo-1(2H)-naphthalene-4-carboxylic acid (3345-77-5)

Guidance literature:

With sulfuric acid; acetic acid; Yield given. Multistep reaction; 1.) 100 deg C, 2.) 115 deg C, 18 h;

DOI:10.1021/jo00303a012

Reference yield:

→ 4-(4-fluorophenyl)-3,4-dihydro-1-oxo-1(2H)-naphthalene-4-carboxylic acid (3345-77-5)

Guidance literature:

aus entspr. Amid;

DOI:10.1021/jo00803a001

Reference yield: 85.0%

4-(4-fluorophenyl)-3,4-dihydro-1-oxo-1(2H)-naphthalene-4-carboxylic acid (3345-77-5) → 4-(4-fluorophenyl)-3,4-dihydro-1(2H)-naphthalen-1-one (79836-47-8,79560-24-0)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; at 100 ℃; for 15h;

DOI:10.1021/jo00303a012

upstream raw materials:

1-amino-2-(methoxycarbonyl)-4-cyano-4-(4-fluorophenyl)-3,4-dihydronaphthalene

Downstream raw materials:

4-(4-fluorophenyl)-3,4-dihydro-1(2H)-naphthalen-1-one