2-(4-(2-(2-(4-chlorophenyl)-2-oxoethylamino)thiazol-4-yl)phenoxy)-2-methyl propanoic acid

Base Information

• Chemical Name: 2-(4-(2-(2-(4-chlorophenyl)-2-oxoethylamino)thiazol-4-yl)phenoxy)-2-methyl propanoic acid
• CAS No.: 1268367-37-8
• Molecular Formula: C₂₁H₁₉ClN₂O₄S
• Molecular Weight: 430.912
• Mol file: 1268367-37-8.mol

Synonyms:2-(4-(2-(2-(4-chlorophenyl)-2-oxoethylamino)thiazol-4-yl)phenoxy)-2-methyl propanoic acid

Chemical Property of 2-(4-(2-(2-(4-chlorophenyl)-2-oxoethylamino)thiazol-4-yl)phenoxy)-2-methyl propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(2-(2-(4-chlorophenyl)-2-oxoethylamino)thiazol-4-yl)phenoxy)-2-methyl propanoic acid

There total 4 articles about 2-(4-(2-(2-(4-chlorophenyl)-2-oxoethylamino)thiazol-4-yl)phenoxy)-2-methyl propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-(4-(2-aminothiazol-4-yl) phenoxy)-2-methylpropanoic acid (1268367-33-4) → 2-(4-(2-(2-(4-chlorophenyl)-2-oxoethylamino)thiazol-4-yl)phenoxy)-2-methyl propanoic acid (1268367-37-8)

Guidance literature:

In benzene; at 80 ℃; for 3h;

DOI:10.1016/j.bmcl.2010.12.011

Reference yield:

2-(p-acetylphenoxy)-2-methylpropionic acid (52179-07-4) → 2-(4-(2-(2-(4-chlorophenyl)-2-oxoethylamino)thiazol-4-yl)phenoxy)-2-methyl propanoic acid (1268367-37-8)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide / 6 h / 20 °C

2: 1 h / 20 °C

3: benzene / 3 h / 80 °C

With N-Bromosuccinimide; In benzene;

DOI:10.1016/j.bmcl.2010.12.011

Reference yield:

4-Hydroxyacetophenone (99-93-4) → 2-(4-(2-(2-(4-chlorophenyl)-2-oxoethylamino)thiazol-4-yl)phenoxy)-2-methyl propanoic acid (1268367-37-8)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / ethanol / 13 h / pH 7 / Reflux

2: N-Bromosuccinimide / 6 h / 20 °C

3: 1 h / 20 °C

4: benzene / 3 h / 80 °C

With N-Bromosuccinimide; potassium carbonate; In ethanol; benzene;

DOI:10.1016/j.bmcl.2010.12.011

upstream raw materials:

2-(4-(2-aminothiazol-4-yl) phenoxy)-2-methylpropanoic acid

2-(p-acetylphenoxy)-2-methylpropionic acid

4-Hydroxyacetophenone