(2-Fluoro-6-methoxy-phenyl)-(2-hydroxy-6-methoxy-phenyl)-methanone

Base Information

• Chemical Name: (2-Fluoro-6-methoxy-phenyl)-(2-hydroxy-6-methoxy-phenyl)-methanone
• CAS No.: 129103-94-2
• Molecular Formula: C₁₅H₁₃FO₄
• Molecular Weight: 276.264
• Mol file: 129103-94-2.mol

Synonyms:(2-Fluoro-6-methoxy-phenyl)-(2-hydroxy-6-methoxy-phenyl)-methanone

Chemical Property of (2-Fluoro-6-methoxy-phenyl)-(2-hydroxy-6-methoxy-phenyl)-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-Fluoro-6-methoxy-phenyl)-(2-hydroxy-6-methoxy-phenyl)-methanone

There total 4 articles about (2-Fluoro-6-methoxy-phenyl)-(2-hydroxy-6-methoxy-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-Fluoro-6-methoxy-benzoic acid 2-iodo-3-methoxy-phenyl ester → (2-Fluoro-6-methoxy-phenyl)-(2-hydroxy-6-methoxy-phenyl)-methanone (129103-94-2)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane; at -70 ℃; for 2h;

DOI:10.1021/jo00302a011

Reference yield:

2-fluoro-6-methoxybenzoyl chloride (500912-12-9) → (2-Fluoro-6-methoxy-phenyl)-(2-hydroxy-6-methoxy-phenyl)-methanone (129103-94-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: 88 percent / n-butyllithium / tetrahydrofuran; diethyl ether; hexane / 2 h / -70 °C

With pyridine; n-butyllithium; In tetrahydrofuran; diethyl ether; hexane;

DOI:10.1021/jo00302a011

Reference yield:

2-fluoro-6-methoxybenzoic acid (137654-21-8) → (2-Fluoro-6-methoxy-phenyl)-(2-hydroxy-6-methoxy-phenyl)-methanone (129103-94-2)

Guidance literature:

Multi-step reaction with 3 steps

1: (COCl)2, DMF / tetrahydrofuran

2: pyridine

3: 88 percent / n-butyllithium / tetrahydrofuran; diethyl ether; hexane / 2 h / -70 °C

With pyridine; n-butyllithium; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether; hexane;

DOI:10.1021/jo00302a011

upstream raw materials:

2-fluoro-6-methoxybenzonitrile

2-fluoro-6-methoxybenzoic acid

2-fluoro-6-methoxybenzoyl chloride