137654-21-8

Basic information

• Product Name: 2-FLUORO-6-METHOXYBENZOIC ACID
• Synonyms: BUTTPARK 20\01-59;2-FLUORO-6-METHOXYBENZOIC ACID;RARECHEM AL BO 0442;2-Fluoro-6-methoxybenzoic acid 98%;6-Fluoro-2-methoxybenzoic acid;6-Fluoro-o-anisic acid;6-Fluoro-o-anisic acid, 2-Carboxy-3-fluoroanisole
• CAS NO: 137654-21-8
• Molecular Formula: C₈H₇FO₃
• Molecular Weight: 170.14
• Product Categories: FINE Chemical & INTERMEDIATES;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;C8;Carbonyl Compounds;Carboxylic Acids;Fluorine series
• Mol File: 137654-21-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 89-93 °C(lit.)
• Boiling Point: 259℃
• Flash Point: 111℃
• Appearance: White to off-white/Crystalline Powder
• Density: 1.307
• Vapor Pressure: 0.00664mmHg at 25°C
• Refractive Index: 1.524
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 3.16±0.10(Predicted)
• CAS DataBase Reference: 2-FLUORO-6-METHOXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-6-METHOXYBENZOIC ACID(137654-21-8)
• EPA Substance Registry System: 2-FLUORO-6-METHOXYBENZOIC ACID(137654-21-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-26-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 137654-21-8(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

Uses

2-Fluoro-6-methoxybenzoic acid may be used as a starting material in the three-step synthesis of dihydro-0-methylsterigmatocystin, a natural mycotoxin.

InChI:InChI=1/C8H7FO3/c1-12-6-4-2-3-5(9)7(6)8(10)11/h2-4H,1H3,(H,10,11)

Upstream product

• 146137-74-8 2-fluoro-6-methoxybenzaldehyde 
• 94088-46-7 2-fluoro-6-methoxybenzonitrile 

Downstream Products

• 844442-07-5 C₂₂H₂₈FN₅O₅ 
• 1516898-03-5 1-methyl-5-methoxy-2-(2'-methoxyphenyl)-4-quinolone 
• 1516898-26-2 C₁₈H₁₈FNO₃ 
• 1516898-16-0 C₁₇H₁₃FO₃ 
• 1516898-08-0 C₂₀H₁₄F₂N₂O₆ 
• 178747-79-0 methyl 2-fluoro-6-methoxybenzoate 
• 911826-36-3 4-fluorobenzofuran-3(2H)-one 
• 911826-38-5 4-fluoro-2,3-dihydrobenzofuran-3-amine 
• 1625611-78-0 C₁₈H₂₀FNO₂ 

Relevant articles and documents

Total synthesis of the ansamycin antibiotic (+)-thiazinotrienomycin E

The first total synthesis of (+)-thiazinotrienomycin E (1), member of a novel class of cytotoxic ansamycin antibiotics, has been achieved. Key features of the synthetic strategy include (a) the efficient construction of sulfone 7 incorporating TBS protection of the aniline, (b) an improved synthesis of allyl chloride (-)-6, the advanced intermediate employed in our trienomycins A and F total syntheses, (c) application of the Kocienski modified Julia protocol to elaborate the E,E,E-triene subunit in a stereo- controlled fashion, (d) an efficient union of sulfone 7 with advanced iodide 62, and (e) Mukaiyama macrolactamization to access the thiazinotrienomycin macrocyclic ring.

A Complex Induced Proximity Effect in the Anionic Fries Rearrangement of o-Iodophenyl Benzoates: Synthesis of Dihydro-O-methylsterigmatocystin and Other Xanthones

The success of an anionic Fries rearrangement, used to synthesise dihydro-O-methylsterigmatocystin and other xanthones, is dependent on the presence of a remote methoxyl substituent.