methyl 1-(4-chlorobutyl)-2-(4-bromophenyl)-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

Base Information

• Chemical Name: methyl 1-(4-chlorobutyl)-2-(4-bromophenyl)-4,5,6,7-tetrahydro-1H-indole-3-carboxylate
• CAS No.: 1048647-88-6
• Molecular Formula: C₂₀H₂₃BrClNO₂
• Molecular Weight: 424.765
• Mol file: 1048647-88-6.mol

Synonyms:methyl 1-(4-chlorobutyl)-2-(4-bromophenyl)-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

Chemical Property of methyl 1-(4-chlorobutyl)-2-(4-bromophenyl)-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 1-(4-chlorobutyl)-2-(4-bromophenyl)-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

There total 2 articles about methyl 1-(4-chlorobutyl)-2-(4-bromophenyl)-4,5,6,7-tetrahydro-1H-indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

pyrrolidine (123-75-1) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + methyl 3-(4-bromophenyl)-3-chloro-2-oxopropionate (146736-29-0) → methyl 1-(4-chlorobutyl)-2-(4-bromophenyl)-4,5,6,7-tetrahydro-1H-indole-3-carboxylate (1048647-88-6)

Guidance literature:

pyrrolidine; cyclohexanone; In benzene; for 1h; Dean-Stark; Reflux;

methyl 3-(4-bromophenyl)-3-chloro-2-oxopropionate; In benzene; for 2h; Dean-Stark; Reflux;

DOI:10.1016/j.tet.2015.10.004

Reference yield: 74.0%

1-(1-Cyclohexen-1-yl)pyrrolidine (1125-99-1) + methyl 3-(4-bromophenyl)-3-chloro-2-oxopropionate (146736-29-0) → methyl 1-(4-chlorobutyl)-2-(4-bromophenyl)-4,5,6,7-tetrahydro-1H-indole-3-carboxylate (1048647-88-6)

Guidance literature:

1-(1-Cyclohexen-1-yl)pyrrolidine; methyl 3-(4-bromophenyl)-3-chloro-2-oxopropionate; In 1,4-dioxane; for 6h; Heating;

With sodium acetate; acetic acid; In 1,4-dioxane; for 2h; Further stages.; Heating;

DOI:10.1016/j.tetlet.2008.05.044

Reference yield: 82.0%

methyl 1-(4-chlorobutyl)-2-(4-bromophenyl)-4,5,6,7-tetrahydro-1H-indole-3-carboxylate (1048647-88-6) → methyl 2-(4-bromophenyl)-1-(4-chlorobutyl)-1H-indole-3-carboxylate

Guidance literature:

With chloranil; In para-xylene; for 17h; Reflux;

DOI:10.1016/j.tet.2015.10.004

upstream raw materials:

1-(1-Cyclohexen-1-yl)pyrrolidine

methyl 3-(4-bromophenyl)-3-chloro-2-oxopropionate

pyrrolidine

cyclohexanone