Technology Process of N'-[(S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-hept-5-enoyl]-hydrazinecarboxylic acid 2,2,2-trichloro-ethyl ester
There total 6 articles about N'-[(S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-hept-5-enoyl]-hydrazinecarboxylic acid 2,2,2-trichloro-ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
Ambient temperature;
DOI:10.1016/0040-4039(92)89014-4
- Guidance literature:
-
Multi-step reaction with 4 steps
1: H2O; acetic acid; diethyl ether
2: 94 percent / Et3N, DMPA / CH2Cl2 / 0 deg C -> room temperature
3: 94 percent / LiOH, H2O / tetrahydrofuran / 50 °C
4: 80 percent / DMAP, 1-hydroxybenzotriazole, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl / CH2Cl2 / Ambient temperature
With
dmap; lithium hydroxide; 0,2,4-dichlorophenyl-0-methylisopropylamidothiophosphate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; acetic acid;
DOI:10.1016/0040-4039(92)89014-4
- Guidance literature:
-
Multi-step reaction with 5 steps
1: K2CO3, H2O / methanol / Ambient temperature
2: H2O; acetic acid; diethyl ether
3: 94 percent / Et3N, DMPA / CH2Cl2 / 0 deg C -> room temperature
4: 94 percent / LiOH, H2O / tetrahydrofuran / 50 °C
5: 80 percent / DMAP, 1-hydroxybenzotriazole, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl / CH2Cl2 / Ambient temperature
With
dmap; lithium hydroxide; 0,2,4-dichlorophenyl-0-methylisopropylamidothiophosphate; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetic acid;
DOI:10.1016/0040-4039(92)89014-4