[(2R,3S)-3-(tert-Butyl-diphenyl-silanyloxy)-2-isopropenyl-6-oxo-piperidin-1-yl]-carbamic acid 2,2,2-trichloro-ethyl ester

Base Information

Chemical Name:[(2R,3S)-3-(tert-Butyl-diphenyl-silanyloxy)-2-isopropenyl-6-oxo-piperidin-1-yl]-carbamic acid 2,2,2-trichloro-ethyl ester
CAS No.:144889-30-5
Molecular Formula:C₂₇H₃₃Cl₃N₂O₄Si
Molecular Weight:584.015
Hs Code.:

Synonyms:[(2R,3S)-3-(tert-Butyl-diphenyl-silanyloxy)-2-isopropenyl-6-oxo-piperidin-1-yl]-carbamic acid 2,2,2-trichloro-ethyl ester

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Chemical Property of [(2R,3S)-3-(tert-Butyl-diphenyl-silanyloxy)-2-isopropenyl-6-oxo-piperidin-1-yl]-carbamic acid 2,2,2-trichloro-ethyl ester

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Technology Process of [(2R,3S)-3-(tert-Butyl-diphenyl-silanyloxy)-2-isopropenyl-6-oxo-piperidin-1-yl]-carbamic acid 2,2,2-trichloro-ethyl ester

There total 7 articles about [(2R,3S)-3-(tert-Butyl-diphenyl-silanyloxy)-2-isopropenyl-6-oxo-piperidin-1-yl]-carbamic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 144708-68-9
N'-[(S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-hept-5-enoyl]-hydrazinecarboxylic acid 2,2,2-trichloro-ethyl ester

: 144889-30-5
[(2R,3S)-3-(tert-Butyl-diphenyl-silanyloxy)-2-isopropenyl-6-oxo-piperidin-1-yl]-carbamic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: With lead(IV) acetate; In dichloromethane; 1.) -20 deg C, 30 min, 2.) -> 0 deg C, 30 min;
DOI:10.1016/0040-4039(92)89014-4

Reference yield:

: (S)-4-Hydroxy-6-methyl-hept-5-enoic acid

: 144889-30-5
[(2R,3S)-3-(tert-Butyl-diphenyl-silanyloxy)-2-isopropenyl-6-oxo-piperidin-1-yl]-carbamic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: H₂O; acetic acid; diethyl ether

2: 94 percent / Et₃N, DMPA / CH₂Cl₂ / 0 deg C -> room temperature

3: 94 percent / LiOH, H₂O / tetrahydrofuran / 50 °C

4: 80 percent / DMAP, 1-hydroxybenzotriazole, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl / CH₂Cl₂ / Ambient temperature

5: 86 percent / lead tetraacetate / CH₂Cl₂ / 1.) -20 deg C, 30 min, 2.) -> 0 deg C, 30 min

With lead(IV) acetate; dmap; lithium hydroxide; 0,2,4-dichlorophenyl-0-methylisopropylamidothiophosphate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetic acid;
DOI:10.1016/0040-4039(92)89014-4

Reference yield:

: 100891-03-0
(S)-5-5(2-methylprop-1-en-1-yl)dihydrofuran-2(3H)-one

: 144889-30-5
[(2R,3S)-3-(tert-Butyl-diphenyl-silanyloxy)-2-isopropenyl-6-oxo-piperidin-1-yl]-carbamic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃, H₂O / methanol / Ambient temperature

2: H₂O; acetic acid; diethyl ether

3: 94 percent / Et₃N, DMPA / CH₂Cl₂ / 0 deg C -> room temperature

4: 94 percent / LiOH, H₂O / tetrahydrofuran / 50 °C

5: 80 percent / DMAP, 1-hydroxybenzotriazole, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl / CH₂Cl₂ / Ambient temperature

6: 86 percent / lead tetraacetate / CH₂Cl₂ / 1.) -20 deg C, 30 min, 2.) -> 0 deg C, 30 min

With lead(IV) acetate; dmap; lithium hydroxide; 0,2,4-dichlorophenyl-0-methylisopropylamidothiophosphate; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetic acid;
DOI:10.1016/0040-4039(92)89014-4