5-chloro-4-[cyclohexyl-(2,2,2-trifluoroacetyl)amino]-2-methoxybenzoic acid methyl ester

Base Information

Chemical Name:5-chloro-4-[cyclohexyl-(2,2,2-trifluoroacetyl)amino]-2-methoxybenzoic acid methyl ester
CAS No.:871932-89-7
Molecular Formula:C₁₇H₁₉ClF₃NO₄
Molecular Weight:393.79
Hs Code.:

Synonyms:5-chloro-4-[cyclohexyl-(2,2,2-trifluoroacetyl)amino]-2-methoxybenzoic acid methyl ester

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Chemical Property of 5-chloro-4-[cyclohexyl-(2,2,2-trifluoroacetyl)amino]-2-methoxybenzoic acid methyl ester

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Technology Process of 5-chloro-4-[cyclohexyl-(2,2,2-trifluoroacetyl)amino]-2-methoxybenzoic acid methyl ester

There total 3 articles about 5-chloro-4-[cyclohexyl-(2,2,2-trifluoroacetyl)amino]-2-methoxybenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 871932-88-6
5-chloro-4-cyclohexylamino-2-methoxybenzoic acid methyl ester

: 76-05-1
trifluoroacetic acid

: 871932-89-7
5-chloro-4-[cyclohexyl-(2,2,2-trifluoroacetyl)amino]-2-methoxybenzoic acid methyl ester

Guidance literature:: With dmap; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 20896-27-9
methyl 4-amino-5-chloro-2-methoxybenzoate

: 871932-89-7
5-chloro-4-[cyclohexyl-(2,2,2-trifluoroacetyl)amino]-2-methoxybenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 50 h / 20 °C

2: dmap / tetrahydrofuran / 2 h / 20 °C

With dmap; sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 7206-70-4
4-amino-5-chloro-2-methoxybenzoic acid

: 871932-89-7
5-chloro-4-[cyclohexyl-(2,2,2-trifluoroacetyl)amino]-2-methoxybenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylsulfide; potassium carbonate / DMF (N,N-dimethyl-formamide) / 15 h / 100 °C

2: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 50 h / 20 °C

3: dmap / tetrahydrofuran / 2 h / 20 °C

With dmap; dimethylsulfide; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); dichloromethane;