N-(2,6-difluoro-3-hydroxy-5-methyl-phenyl)-2-fluoro-5-(3-fluorophenyl)benzamide

Base Information

• Chemical Name: N-(2,6-difluoro-3-hydroxy-5-methyl-phenyl)-2-fluoro-5-(3-fluorophenyl)benzamide
• CAS No.: 1427407-75-7
• Molecular Formula: C₂₀H₁₃F₄NO₂
• Molecular Weight: 375.322
• Mol file: 1427407-75-7.mol

Synonyms:N-(2,6-difluoro-3-hydroxy-5-methyl-phenyl)-2-fluoro-5-(3-fluorophenyl)benzamide

Chemical Property of N-(2,6-difluoro-3-hydroxy-5-methyl-phenyl)-2-fluoro-5-(3-fluorophenyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2,6-difluoro-3-hydroxy-5-methyl-phenyl)-2-fluoro-5-(3-fluorophenyl)benzamide

There total 10 articles about N-(2,6-difluoro-3-hydroxy-5-methyl-phenyl)-2-fluoro-5-(3-fluorophenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H7ClF2O (1214382-15-6) + 3-amino-2,4-difluoro-5-methylphenol (1427407-74-6) → N-(2,6-difluoro-3-hydroxy-5-methyl-phenyl)-2-fluoro-5-(3-fluorophenyl)benzamide (1427407-75-7)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield:

2-(2,4-difluoro-5-methyl-phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1427407-71-3) → N-(2,6-difluoro-3-hydroxy-5-methyl-phenyl)-2-fluoro-5-(3-fluorophenyl)benzamide (1427407-75-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: dihydrogen peroxide; water; sodium hydroxide / tetrahydrofuran / 4 h / 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -60 °C / Inert atmosphere

3.2: 1 h / -60 - 20 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 - 20 °C

4.2: 0 - 70 °C

5.1: potassium hydroxide; water / 1,4-dioxane / Reflux

6.1: tetrahydrofuran / 2 h / 0 - 20 °C

With 1H-imidazole; n-butyllithium; oxalyl dichloride; water; dihydrogen peroxide; N,N-dimethyl-formamide; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

1-bromo-2,4-difluoro-5-methylbenzene (159277-47-1) → N-(2,6-difluoro-3-hydroxy-5-methyl-phenyl)-2-fluoro-5-(3-fluorophenyl)benzamide (1427407-75-7)

Guidance literature:

Multi-step reaction with 7 steps

1.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 90 °C / Inert atmosphere

2.1: dihydrogen peroxide; water; sodium hydroxide / tetrahydrofuran / 4 h / 20 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -60 °C / Inert atmosphere

4.2: 1 h / -60 - 20 °C

5.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 - 20 °C

5.2: 0 - 70 °C

6.1: potassium hydroxide; water / 1,4-dioxane / Reflux

7.1: tetrahydrofuran / 2 h / 0 - 20 °C

With 1H-imidazole; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; n-butyllithium; oxalyl dichloride; water; dihydrogen peroxide; potassium acetate; N,N-dimethyl-formamide; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

upstream raw materials:

C₁₃H₇ClF₂O

3-amino-2,4-difluoro-5-methylphenol

2-(2,4-difluoro-5-methyl-phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

1-bromo-2,4-difluoro-5-methylbenzene

Downstream raw materials:

2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-5-methylphenol

C₂₅H₂₃F₄NO₃

C₂₂H₁₇F₄NO₃