2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-5-methylphenol

Base Information

Chemical Name:2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-5-methylphenol
CAS No.:1427407-76-8
Molecular Formula:C₂₀H₁₅F₄NO
Molecular Weight:361.339
Hs Code.:

Synonyms:2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-5-methylphenol

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Chemical Property of 2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-5-methylphenol

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Technology Process of 2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-5-methylphenol

There total 12 articles about 2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-5-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1427407-75-7
N-(2,6-difluoro-3-hydroxy-5-methyl-phenyl)-2-fluoro-5-(3-fluorophenyl)benzamide

: 1427407-76-8
2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-5-methylphenol

Guidance literature:: With borane-THF; In tetrahydrofuran; at 60 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1214382-15-6
C₁₃H₇ClF₂O

: 1427407-76-8
2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-5-methylphenol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 2 h / 0 - 20 °C

2: borane-THF / tetrahydrofuran / 2 h / 60 °C / Inert atmosphere

With borane-THF; In tetrahydrofuran;

Reference yield:

: 1427407-71-3
2-(2,4-difluoro-5-methyl-phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1427407-76-8
2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-5-methylphenol

Guidance literature:: Multi-step reaction with 7 steps

1.1: dihydrogen peroxide; water; sodium hydroxide / tetrahydrofuran / 4 h / 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -60 °C / Inert atmosphere

3.2: 1 h / -60 - 20 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 - 20 °C

4.2: 0 - 70 °C

5.1: potassium hydroxide; water / 1,4-dioxane / Reflux

6.1: tetrahydrofuran / 2 h / 0 - 20 °C

7.1: borane-THF / tetrahydrofuran / 2 h / 60 °C / Inert atmosphere

With 1H-imidazole; n-butyllithium; borane-THF; oxalyl dichloride; water; dihydrogen peroxide; N,N-dimethyl-formamide; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide;