tert-butyl 2-(3-(chlorocarbonyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)acetate

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Chemical Name:tert-butyl 2-(3-(chlorocarbonyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)acetate
CAS No.:1454705-52-2
Molecular Formula:C₂₁H₁₉Cl₃N₂O₄
Molecular Weight:469.752
Hs Code.:

Synonyms:tert-butyl 2-(3-(chlorocarbonyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)acetate

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Chemical Property of tert-butyl 2-(3-(chlorocarbonyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)acetate

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Technology Process of tert-butyl 2-(3-(chlorocarbonyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)acetate

There total 6 articles about tert-butyl 2-(3-(chlorocarbonyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 915297-05-1
6-(2-tert-butoxy-2-oxoethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylic acid

: 1454705-52-2
tert-butyl 2-(3-(chlorocarbonyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)acetate

Guidance literature:: With trichloroacetonitrile; triphenylphosphine; In chloroform; at 20 ℃; for 3h;

Reference yield:

: 915296-79-6
(Z)-ethyl 4-chloro-2-(2,4-dichlorobenzylidene)-3-oxobutanoate

: 1454705-52-2
tert-butyl 2-(3-(chlorocarbonyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: isopropyl alcohol / 18 h / 20 °C / Inert atmosphere

2: acetic acid; nitric acid / water / 18 h / 20 °C / Inert atmosphere

3: ethanol / 150 °C / Microwave irradiation; Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 20 °C / Inert atmosphere

5: trichloroacetonitrile / dichloromethane / 3 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; nitric acid; acetic acid; trichloroacetonitrile; In ethanol; dichloromethane; water; ethyl acetate; isopropyl alcohol;
DOI:10.1021/jm4008906

Reference yield:

: 915297-04-0
benzyl 6-(2-tert-butoxy-2-oxoethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylate

: 1454705-52-2
tert-butyl 2-(3-(chlorocarbonyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 20 °C / Inert atmosphere

2: trichloroacetonitrile / dichloromethane / 3 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; trichloroacetonitrile; In dichloromethane; ethyl acetate;
DOI:10.1021/jm4008906