Technology Process of 2-(2-ethyl-4-(5-(3-ethyl-5,5-dimethyl-4,5,6,7-tetrahydrobenzo[c]thiophen-1-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)ethanol
There total 8 articles about 2-(2-ethyl-4-(5-(3-ethyl-5,5-dimethyl-4,5,6,7-tetrahydrobenzo[c]thiophen-1-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)ethanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
water; isopropyl alcohol;
at 65 ℃;
for 66h;
DOI:10.1021/jm401456d
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C / 750.08 Torr
2.1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 0.5 h / 20 °C / Cooling with ice
2.2: 0.83 h / 15 - 20 °C
3.1: oxalyl dichloride / chloroform / 1 h / 20 - 25 °C
4.1: sodium; ethanol / tetrahydrofuran / 1 h / 20 °C
5.1: sodium; ethanol / 0.25 h / 50 - 75 °C
6.1: water; lithium hydroxide / ethanol / 70 °C
7.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C
7.2: 18 h / 20 °C
8.1: sodium hydroxide / isopropyl alcohol; water / 66 h / 65 °C
With
oxalyl dichloride; ethanol; palladium 10% on activated carbon; potassium tert-butylate; water; hydrogen; sodium; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide;
In
tetrahydrofuran; ethanol; chloroform; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; tert-butyl alcohol;
DOI:10.1021/jm401456d
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium; ethanol / 0.25 h / 50 - 75 °C
2.1: water; lithium hydroxide / ethanol / 70 °C
3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C
3.2: 18 h / 20 °C
4.1: sodium hydroxide / isopropyl alcohol; water / 66 h / 65 °C
With
ethanol; water; sodium; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide;
In
ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm401456d
