(R)-2-((4S,5R)-2-Oxo-4,5-diphenyl-oxazolidin-3-yl)-pent-4-enoic acid benzyl ester

Base Information

Chemical Name:(R)-2-((4S,5R)-2-Oxo-4,5-diphenyl-oxazolidin-3-yl)-pent-4-enoic acid benzyl ester
CAS No.:161633-98-3
Molecular Formula:C₂₇H₂₅NO₄
Molecular Weight:427.5
Hs Code.:

Synonyms:(R)-2-((4S,5R)-2-Oxo-4,5-diphenyl-oxazolidin-3-yl)-pent-4-enoic acid benzyl ester

Suppliers and Price of (R)-2-((4S,5R)-2-Oxo-4,5-diphenyl-oxazolidin-3-yl)-pent-4-enoic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-2-((4S,5R)-2-Oxo-4,5-diphenyl-oxazolidin-3-yl)-pent-4-enoic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-2-((4S,5R)-2-Oxo-4,5-diphenyl-oxazolidin-3-yl)-pent-4-enoic acid benzyl ester

There total 3 articles about (R)-2-((4S,5R)-2-Oxo-4,5-diphenyl-oxazolidin-3-yl)-pent-4-enoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1826-67-1
vinyl magnesium bromide

: 161633-84-7
2-((4S,5R)-2-Oxo-4,5-diphenyl-oxazolidin-3-yl)-acrylic acid benzyl ester

: 161633-98-3
(R)-2-((4S,5R)-2-Oxo-4,5-diphenyl-oxazolidin-3-yl)-pent-4-enoic acid benzyl ester

Guidance literature:: With copper(l) iodide; In tetrahydrofuran; a) -78 deg C, 120 min, b) -10 deg C, 30 min;
DOI:10.1021/ja00097a020

Reference yield:

: 161633-83-6
2-((4S,5R)-2-Oxo-4,5-diphenyl-oxazolidin-3-yl)-acrylic acid

: 161633-98-3
(R)-2-((4S,5R)-2-Oxo-4,5-diphenyl-oxazolidin-3-yl)-pent-4-enoic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / dimethylformamide / 19 h

2: 74 percent / CuI / tetrahydrofuran / a) -78 deg C, 120 min, b) -10 deg C, 30 min

With copper(l) iodide; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja00097a020

Reference yield:

: (4S,5R)-4,5-Diphenyl-3-(1-trimethylstannanyl-vinyl)-oxazolidin-2-one

: 161633-98-3
(R)-2-((4S,5R)-2-Oxo-4,5-diphenyl-oxazolidin-3-yl)-pent-4-enoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, Et₂O, pentane, hexane, -100 deg C, 30 min, 2.) THF, Et₂O, pentane, hexane, from -100 deg C to RT

2: Et₃N / dimethylformamide / 19 h

3: 74 percent / CuI / tetrahydrofuran / a) -78 deg C, 120 min, b) -10 deg C, 30 min

With copper(l) iodide; n-butyllithium; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja00097a020