methyl 3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanoate

Base Information

• Chemical Name: methyl 3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanoate
• CAS No.: 1000167-13-4
• Molecular Formula: C₁₂H₁₂N₂O₃
• Molecular Weight: 232.239
• Mol file: 1000167-13-4.mol

Synonyms:methyl 3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanoate

Chemical Property of methyl 3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanoate

There total 2 articles about methyl 3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

methyl 4-(2-benzoylhydrazino)-4-oxobutanoate (304480-84-0) → methyl 3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanoate (1000167-13-4)

Guidance literature:

With pyridine; thionyl chloride; In tetrahydrofuran; toluene; at 20 ℃; for 3h; Heating / reflux;

Reference yield: 60.0%

4-bromo-4-nitro-butyric acid methyl ester + benzoic acid hydrazide (613-94-5) → methyl 3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanoate (1000167-13-4)

Guidance literature:

With urea hydrogen peroxide adduct; potassium carbonate; potassium iodide; In 1,2-dimethoxyethane; water; at 20 ℃; for 2h;

DOI:10.1039/c7sc00195a

Reference yield: 83.0%

methyl 3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanoate (1000167-13-4) → 3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanoic acid (23464-98-4)

Guidance literature:

methyl 3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanoate; With sodium hydroxide; water; In methanol; at 20 ℃;

In methanol; pH=5; Acidic conditions;

upstream raw materials:

methyl 4-(2-benzoylhydrazino)-4-oxobutanoate

benzoic acid hydrazide

Downstream raw materials:

3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanoic acid

Refernces

• 1、 -. "PURINONE DERIVATIVES AS HM74A AGONISTS". Page/Page column 70. . Retrieved 2008/06/13.