1,1-dimethylethyl ((1R)-1-{[(2-{[3-(ethyloxy)-4-methylphenyl]oxy}-5-pyrimidinyl)amino]carbonyl}propyl)carbamate

Base Information

Chemical Name:1,1-dimethylethyl ((1R)-1-{[(2-{[3-(ethyloxy)-4-methylphenyl]oxy}-5-pyrimidinyl)amino]carbonyl}propyl)carbamate
CAS No.:1311138-48-3
Molecular Formula:C₂₂H₃₀N₄O₅
Molecular Weight:430.504
Hs Code.:

Synonyms:1,1-dimethylethyl ((1R)-1-{[(2-{[3-(ethyloxy)-4-methylphenyl]oxy}-5-pyrimidinyl)amino]carbonyl}propyl)carbamate

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Chemical Property of 1,1-dimethylethyl ((1R)-1-{[(2-{[3-(ethyloxy)-4-methylphenyl]oxy}-5-pyrimidinyl)amino]carbonyl}propyl)carbamate

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Technology Process of 1,1-dimethylethyl ((1R)-1-{[(2-{[3-(ethyloxy)-4-methylphenyl]oxy}-5-pyrimidinyl)amino]carbonyl}propyl)carbamate

There total 7 articles about 1,1-dimethylethyl ((1R)-1-{[(2-{[3-(ethyloxy)-4-methylphenyl]oxy}-5-pyrimidinyl)amino]carbonyl}propyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1311138-47-2
2-{[3-(ethyloxy)-4-methylphenyl]oxy}-5-pyrimidinamine

: 45121-22-0
Boc-D-Abu

: 1311138-48-3
1,1-dimethylethyl ((1R)-1-{[(2-{[3-(ethyloxy)-4-methylphenyl]oxy}-5-pyrimidinyl)amino]carbonyl}propyl)carbamate

Guidance literature:: Boc-D-Abu; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

2-{[3-(ethyloxy)-4-methylphenyl]oxy}-5-pyrimidinamine; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

Reference yield:

: 5428-54-6
2-methyl-5-nitrophenol

: 1311138-48-3
1,1-dimethylethyl ((1R)-1-{[(2-{[3-(ethyloxy)-4-methylphenyl]oxy}-5-pyrimidinyl)amino]carbonyl}propyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / acetone / 48 h / Reflux

2.1: water; ammonium chloride / iron / tetrahydrofuran / Inert atmosphere

3.1: water; sodium nitrite; sulfuric acid / 2.75 h / 0 - 90 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

5.1: water; ammonium chloride / iron / tetrahydrofuran / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C

6.2: 48 h / 20 °C

With sulfuric acid; water; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; sodium nitrite; iron; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;

Reference yield:

: 676224-74-1
3-ethoxy-4-methyl-phenol

: 1311138-48-3
1,1-dimethylethyl ((1R)-1-{[(2-{[3-(ethyloxy)-4-methylphenyl]oxy}-5-pyrimidinyl)amino]carbonyl}propyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2.1: water; ammonium chloride / iron / tetrahydrofuran / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 48 h / 20 °C

With water; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; iron; In tetrahydrofuran; N,N-dimethyl-formamide;