(S,S)-3-(2-methoxycarbonylamino-3-methylbutyryl)-1-phenylimidazolidine-4-carboxlic acid methyl ester

Base Information

Chemical Name:(S,S)-3-(2-methoxycarbonylamino-3-methylbutyryl)-1-phenylimidazolidine-4-carboxlic acid methyl ester
CAS No.:1256387-15-1
Molecular Formula:C₁₈H₂₅N₃O₅
Molecular Weight:363.414
Hs Code.:

Synonyms:(S,S)-3-(2-methoxycarbonylamino-3-methylbutyryl)-1-phenylimidazolidine-4-carboxlic acid methyl ester

Suppliers and Price of (S,S)-3-(2-methoxycarbonylamino-3-methylbutyryl)-1-phenylimidazolidine-4-carboxlic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S,S)-3-(2-methoxycarbonylamino-3-methylbutyryl)-1-phenylimidazolidine-4-carboxlic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S,S)-3-(2-methoxycarbonylamino-3-methylbutyryl)-1-phenylimidazolidine-4-carboxlic acid methyl ester

There total 3 articles about (S,S)-3-(2-methoxycarbonylamino-3-methylbutyryl)-1-phenylimidazolidine-4-carboxlic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1256386-94-3
(S,S)-3-(2-methoxycarbonylamino-3-methylbutyryl)imidazolidine-1,4-dicarboxlic acid 1-tert-butyl ester 4-methyl ester

: 98-80-6
phenylboronic acid

: 1256387-15-1
(S,S)-3-(2-methoxycarbonylamino-3-methylbutyryl)-1-phenylimidazolidine-4-carboxlic acid methyl ester

Guidance literature:: (S,S)-3-(2-methoxycarbonylamino-3-methylbutyryl)imidazolidine-1,4-dicarboxlic acid 1-tert-butyl ester 4-methyl ester; With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 1h;

phenylboronic acid; With copper diacetate; triethylamine; In dichloromethane; at 20 ℃; for 24h; Molecular sieves 4A;

With ammonium hydroxide; In dichloromethane; water;

Reference yield:

: 1256386-92-1
(S)-1-benzylimidazolidine-4-carboxlic acid methyl ester

: 1256387-15-1
(S,S)-3-(2-methoxycarbonylamino-3-methylbutyryl)-1-phenylimidazolidine-4-carboxlic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C

2.2: 1 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 20 °C

3.2: 24 h / 20 °C / Molecular sieves 4A

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1256386-93-2
(S,S)-1-benzyl-3-(2-methoxycarbonylamino-3-methylbutyryl)imidazolidine-4-carboxlic acid methyl ester

: 1256387-15-1
(S,S)-3-(2-methoxycarbonylamino-3-methylbutyryl)-1-phenylimidazolidine-4-carboxlic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C

1.2: 1 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 20 °C

2.2: 24 h / 20 °C / Molecular sieves 4A

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane;