9-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-3,4-dihydropyrido[2,3-f ][1,4]oxazepin-5(2H)-one

Base Information

• Chemical Name: 9-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-3,4-dihydropyrido[2,3-f ][1,4]oxazepin-5(2H)-one
• CAS No.: 1383377-66-9
• Molecular Formula: C₁₈H₁₅FN₄O₂
• Molecular Weight: 338.341
• Mol file: 1383377-66-9.mol

Synonyms:9-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-3,4-dihydropyrido[2,3-f ][1,4]oxazepin-5(2H)-one

Chemical Property of 9-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-3,4-dihydropyrido[2,3-f ][1,4]oxazepin-5(2H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-3,4-dihydropyrido[2,3-f ][1,4]oxazepin-5(2H)-one

There total 10 articles about 9-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-3,4-dihydropyrido[2,3-f ][1,4]oxazepin-5(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-(2-aminoethoxy)-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)picolinonitrile dihydrochloride → 9-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-3,4-dihydropyrido[2,3-f ][1,4]oxazepin-5(2H)-one (1383377-66-9)

Guidance literature:

With water; sodium hydroxide; for 2h; Reflux;

Reference yield:

3-(2-aminoethoxy)-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)picolinonitrile → 9-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-3,4-dihydropyrido[2,3-f ][1,4]oxazepin-5(2H)-one (1383377-66-9)

Guidance literature:

With water; sodium hydroxide; In aq. phosphate buffer; at -10 - 110 ℃; for 3h; pH=7;

DOI:10.1021/jm4006324

Reference yield:

4-bromo-3-(4-fluorophenyl)-1-methyl-1H-pyrazole (863605-34-9) → 9-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-3,4-dihydropyrido[2,3-f ][1,4]oxazepin-5(2H)-one (1383377-66-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 3 h / 20 - 25 °C

1.2: 10 - 20 °C

1.3: 10 - 25 °C

2.1: caesium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / N,N-dimethyl-formamide / 20 - 50 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C

3.2: 0.5 h / 20 °C

4.1: hydrogenchloride; water / 0.5 h / Reflux

5.1: sodium hydroxide; water / 2 h / Reflux

With hydrogenchloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; water; isopropylmagnesium chloride; sodium hydride; caesium carbonate; lithium chloride; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

4-fluorobenzoic acid ethyl ester

3-fluoro-4-methylpyridine

4-bromo-3-(4-fluorophenyl)-1-methyl-1H-pyrazole

3-(4-fluorophenyl)-1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Downstream raw materials:

9-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-2,3,4,5-tetrahydropyrido[2,3-f ][1,4]oxazepine