9-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-2,3,4,5-tetrahydropyrido[2,3-f ][1,4]oxazepine

Base Information

• Chemical Name: 9-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-2,3,4,5-tetrahydropyrido[2,3-f ][1,4]oxazepine
• CAS No.: 1383376-98-4
• Molecular Formula: C₁₈H₁₇FN₄O
• Molecular Weight: 324.358
• Mol file: 1383376-98-4.mol

Synonyms:9-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-2,3,4,5-tetrahydropyrido[2,3-f ][1,4]oxazepine

Chemical Property of 9-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-2,3,4,5-tetrahydropyrido[2,3-f ][1,4]oxazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-2,3,4,5-tetrahydropyrido[2,3-f ][1,4]oxazepine

There total 12 articles about 9-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-2,3,4,5-tetrahydropyrido[2,3-f ][1,4]oxazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

9-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-3,4-dihydropyrido[2,3-f ][1,4]oxazepin-5(2H)-one (1383377-66-9) → 9-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-2,3,4,5-tetrahydropyrido[2,3-f ][1,4]oxazepine (1383376-98-4)

Guidance literature:

With lithium aluminium tetrahydride; water; In tetrahydrofuran; for 1h; Reflux;

Reference yield:

4-bromo-3-(4-fluorophenyl)-1-methyl-1H-pyrazole (863605-34-9) → 9-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-2,3,4,5-tetrahydropyrido[2,3-f ][1,4]oxazepine (1383376-98-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 3 h / 20 - 25 °C

1.2: 10 - 20 °C

1.3: 10 - 25 °C

2.1: caesium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / N,N-dimethyl-formamide / 20 - 50 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C

3.2: 0.5 h / 20 °C

4.1: hydrogenchloride; water / 0.5 h / Reflux

5.1: sodium hydroxide; water / 2 h / Reflux

6.1: lithium aluminium tetrahydride; water / tetrahydrofuran / 1 h / Reflux

With hydrogenchloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; lithium aluminium tetrahydride; water; isopropylmagnesium chloride; sodium hydride; caesium carbonate; lithium chloride; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

3-(4-fluorophenyl)-1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (1286230-78-1) → 9-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-2,3,4,5-tetrahydropyrido[2,3-f ][1,4]oxazepine (1383376-98-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: caesium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / N,N-dimethyl-formamide / 20 - 50 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: hydrogenchloride; water / 0.5 h / Reflux

4.1: sodium hydroxide; water / 2 h / Reflux

5.1: lithium aluminium tetrahydride; water / tetrahydrofuran / 1 h / Reflux

With hydrogenchloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; lithium aluminium tetrahydride; water; sodium hydride; caesium carbonate; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

4-bromo-3-(4-fluorophenyl)-1-methyl-1H-pyrazole

3-(4-fluorophenyl)-1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

3-fluoro-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridine

3-fluoro-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridine 1-oxide