{5-[[5-(hydroxy-phenyl-methyl)-1H-pyrrol-2-yl]-(4-methoxy-phenyl)-methyl]-1H-pyrrol-2-yl}-pentafluorophenyl-methanol

Base Information

• Chemical Name: {5-[[5-(hydroxy-phenyl-methyl)-1H-pyrrol-2-yl]-(4-methoxy-phenyl)-methyl]-1H-pyrrol-2-yl}-pentafluorophenyl-methanol
• CAS No.: 1026222-33-2
• Molecular Formula: C₃₀H₂₃F₅N₂O₃
• Molecular Weight: 554.516

Synonyms:{5-[[5-(hydroxy-phenyl-methyl)-1H-pyrrol-2-yl]-(4-methoxy-phenyl)-methyl]-1H-pyrrol-2-yl}-pentafluorophenyl-methanol

Chemical Property of {5-[[5-(hydroxy-phenyl-methyl)-1H-pyrrol-2-yl]-(4-methoxy-phenyl)-methyl]-1H-pyrrol-2-yl}-pentafluorophenyl-methanol

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Technology Process of {5-[[5-(hydroxy-phenyl-methyl)-1H-pyrrol-2-yl]-(4-methoxy-phenyl)-methyl]-1H-pyrrol-2-yl}-pentafluorophenyl-methanol

There total 3 articles about {5-[[5-(hydroxy-phenyl-methyl)-1H-pyrrol-2-yl]-(4-methoxy-phenyl)-methyl]-1H-pyrrol-2-yl}-pentafluorophenyl-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzoyl-5-(4-methoxyphenyl)-9-(pentafluorobenzoyl)dipyrromethane (307930-95-6) → {5-[[5-(hydroxy-phenyl-methyl)-1H-pyrrol-2-yl]-(4-methoxy-phenyl)-methyl]-1H-pyrrol-2-yl}-pentafluorophenyl-methanol (1026222-33-2)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 20 ℃; for 0.666667h;

DOI:10.1021/jo000882k

Reference yield:

pentafluorobenzoylchloride (2251-50-5) → {5-[[5-(hydroxy-phenyl-methyl)-1H-pyrrol-2-yl]-(4-methoxy-phenyl)-methyl]-1H-pyrrol-2-yl}-pentafluorophenyl-methanol (1026222-33-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: EtMgBr / toluene; tetrahydrofuran / 0.17 h / 20 °C

1.2: 49 percent / toluene / 0.5 h / 20 °C

2.1: NaBH₄ / tetrahydrofuran; methanol / 0.67 h / 20 °C

With sodium tetrahydroborate; ethylmagnesium bromide; In tetrahydrofuran; methanol; toluene; 1.1: Metallation / 1.2: Acylation / 2.1: Reduction;

DOI:10.1021/jo000882k

Reference yield:

1-benzoyl-5-(4-methoxyphenyl)dipyrromethane (262267-44-7) → {5-[[5-(hydroxy-phenyl-methyl)-1H-pyrrol-2-yl]-(4-methoxy-phenyl)-methyl]-1H-pyrrol-2-yl}-pentafluorophenyl-methanol (1026222-33-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: EtMgBr / toluene; tetrahydrofuran / 0.17 h / 20 °C

1.2: 49 percent / toluene / 0.5 h / 20 °C

2.1: NaBH₄ / tetrahydrofuran; methanol / 0.67 h / 20 °C

With sodium tetrahydroborate; ethylmagnesium bromide; In tetrahydrofuran; methanol; toluene; 1.1: Metallation / 1.2: Acylation / 2.1: Reduction;

DOI:10.1021/jo000882k

upstream raw materials:

1-benzoyl-5-(4-methoxyphenyl)-9-(pentafluorobenzoyl)dipyrromethane

pentafluorobenzoylchloride

1-benzoyl-5-(4-methoxyphenyl)dipyrromethane

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