2-methylpropane-2-sulfinic acid {(S)-1-[4-(2-amino-4-fluorophenyl)pyridin-2-yl]but-3-enyl}amide

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Chemical Name:2-methylpropane-2-sulfinic acid {(S)-1-[4-(2-amino-4-fluorophenyl)pyridin-2-yl]but-3-enyl}amide
CAS No.:1329169-87-0
Molecular Formula:C₁₉H₂₄FN₃OS
Molecular Weight:361.483
Hs Code.:

Synonyms:2-methylpropane-2-sulfinic acid {(S)-1-[4-(2-amino-4-fluorophenyl)pyridin-2-yl]but-3-enyl}amide

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Chemical Property of 2-methylpropane-2-sulfinic acid {(S)-1-[4-(2-amino-4-fluorophenyl)pyridin-2-yl]but-3-enyl}amide

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Technology Process of 2-methylpropane-2-sulfinic acid {(S)-1-[4-(2-amino-4-fluorophenyl)pyridin-2-yl]but-3-enyl}amide

There total 3 articles about 2-methylpropane-2-sulfinic acid {(S)-1-[4-(2-amino-4-fluorophenyl)pyridin-2-yl]but-3-enyl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.9%

: (S)-N-(1-(4-chloropyridin-2-yl)but-3-enyl)-2-methylpropane-2-sulfinamide

: 1329169-86-9
2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5-fluorophenylamine

: 1329169-87-0
2-methylpropane-2-sulfinic acid {(S)-1-[4-(2-amino-4-fluorophenyl)pyridin-2-yl]but-3-enyl}amide

Guidance literature:: With potassium phosphate; water; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dimethyl sulfoxide; at 90 ℃; for 2h; Inert atmosphere;

Reference yield:

: 63071-13-6
4-chloro-2-pyridinecarbaldehyde

: 1329169-87-0
2-methylpropane-2-sulfinic acid {(S)-1-[4-(2-amino-4-fluorophenyl)pyridin-2-yl]but-3-enyl}amide

Guidance literature:: Multi-step reaction with 3 steps

1: copper(II) sulfate / dichloromethane / 3 h / 20 °C

2: diethyl ether; tetrahydrofuran / -78 °C

3: potassium phosphate; water / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 2 h / 90 °C / Inert atmosphere

With potassium phosphate; water; copper(II) sulfate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1329167-86-3
(S)-N-[(1E)-(4-chloropyridin-2-yl)methylidene]-2-methylpropane-2-sulfinamide

: 1329169-87-0
2-methylpropane-2-sulfinic acid {(S)-1-[4-(2-amino-4-fluorophenyl)pyridin-2-yl]but-3-enyl}amide

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether; tetrahydrofuran / -78 °C

2: potassium phosphate; water / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 2 h / 90 °C / Inert atmosphere

With potassium phosphate; water; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;