4-benzyl-piperazine-1-N,N'-bis(tert-butoxycarbonyl)carboxamidine

Base Information

• Chemical Name: 4-benzyl-piperazine-1-N,N'-bis(tert-butoxycarbonyl)carboxamidine
• CAS No.: 400785-59-3
• Molecular Formula: C₂₂H₃₄N₄O₄
• Molecular Weight: 418.536
• Mol file: 400785-59-3.mol

Synonyms:4-benzyl-piperazine-1-N,N'-bis(tert-butoxycarbonyl)carboxamidine

Chemical Property of 4-benzyl-piperazine-1-N,N'-bis(tert-butoxycarbonyl)carboxamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-benzyl-piperazine-1-N,N'-bis(tert-butoxycarbonyl)carboxamidine

There total 1 articles about 4-benzyl-piperazine-1-N,N'-bis(tert-butoxycarbonyl)carboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-phenylmethylpiperazine (2759-28-6) + tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate (145013-05-4) → 4-benzyl-piperazine-1-N,N'-bis(tert-butoxycarbonyl)carboxamidine (400785-59-3)

Guidance literature:

1-phenylmethylpiperazine; tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate; With polymer-supported carbodiimide; In dichloromethane; at 20 ℃; for 16h;

With 2,2',2''-triaminotriethylamine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1016/S0040-4039(02)01390-4

Reference yield:

4-benzyl-piperazine-1-N,N'-bis(tert-butoxycarbonyl)carboxamidine (400785-59-3) → 4-benzylpiperazine-1-carboximidamide (7773-69-5,105735-38-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1016/S0040-4039(02)01390-4

Reference yield:

trifluoroacetic acid (76-05-1) + 4-benzyl-piperazine-1-N,N'-bis(tert-butoxycarbonyl)carboxamidine (400785-59-3) → 4-benzyl-piperazine-1-carboxamidine bis(trifluoroacetate)

Guidance literature:

In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/jm010440g

upstream raw materials:

1-phenylmethylpiperazine

tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate

Downstream raw materials:

4-benzylpiperazine-1-carboximidamide