Acetic acid (S)-2-((S)-4-ethynyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-(4-methoxy-benzyloxy)-ethyl ester

Base Information

• Chemical Name: Acetic acid (S)-2-((S)-4-ethynyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-(4-methoxy-benzyloxy)-ethyl ester
• CAS No.: 365450-53-9
• Molecular Formula: C₁₉H₂₄O₆
• Molecular Weight: 348.396

Synonyms:Acetic acid (S)-2-((S)-4-ethynyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-(4-methoxy-benzyloxy)-ethyl ester

Chemical Property of Acetic acid (S)-2-((S)-4-ethynyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-(4-methoxy-benzyloxy)-ethyl ester

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Technology Process of Acetic acid (S)-2-((S)-4-ethynyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-(4-methoxy-benzyloxy)-ethyl ester

There total 3 articles about Acetic acid (S)-2-((S)-4-ethynyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-(4-methoxy-benzyloxy)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-Methoxypropene (116-11-0) + Acetic acid (2S,3S)-3-hydroxy-3-hydroxymethyl-2-(4-methoxy-benzyloxy)-pent-4-ynyl ester → Acetic acid (S)-2-((S)-4-ethynyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-(4-methoxy-benzyloxy)-ethyl ester (365450-53-9)

Guidance literature:

With pyridinium p-toluenesulfonate; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(01)00959-5

Reference yield:

(2S,3S)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(4-methoxy-benzyloxy)-pent-4-yne-1,3-diol → Acetic acid (S)-2-((S)-4-ethynyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-(4-methoxy-benzyloxy)-ethyl ester (365450-53-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / DMAP; pyridine / CH₂Cl₂

2: PPTS / methanol

3: 84 percent / PPTS / dimethylformamide

With pyridine; dmap; pyridinium p-toluenesulfonate; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(01)00959-5

Reference yield:

Acetic acid (2S,3S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-2-(4-methoxy-benzyloxy)-pent-4-ynyl ester → Acetic acid (S)-2-((S)-4-ethynyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-(4-methoxy-benzyloxy)-ethyl ester (365450-53-9)

Guidance literature:

Multi-step reaction with 2 steps

1: PPTS / methanol

2: 84 percent / PPTS / dimethylformamide

With pyridinium p-toluenesulfonate; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(01)00959-5

upstream raw materials:

2-Methoxypropene

Downstream raw materials:

C₅₂H₆₇ClN₂O₁₃SSi

C₄₇H₆₄ClNO₁₄Si

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