4-(1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-h][1,6]naphthyridin-5-oxo)benzaldehyde

Base Information

Chemical Name:4-(1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-h][1,6]naphthyridin-5-oxo)benzaldehyde
CAS No.:1422434-16-9
Molecular Formula:C₂₉H₂₅Cl₂N₅O₃
Molecular Weight:562.455
Hs Code.:

Synonyms:4-(1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-h][1,6]naphthyridin-5-oxo)benzaldehyde

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Chemical Property of 4-(1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-h][1,6]naphthyridin-5-oxo)benzaldehyde

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Technology Process of 4-(1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-h][1,6]naphthyridin-5-oxo)benzaldehyde

There total 7 articles about 4-(1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-h][1,6]naphthyridin-5-oxo)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.4%

: 1422434-16-9
4-(1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-h][1,6]naphthyridin-5-oxo)benzaldehyde

Guidance literature:: With trifluoroacetic acid; In dichloromethane;

Reference yield:

: 1422434-46-5
C₃₄H₃₃Cl₂N₅O₅

: 1422434-16-9
4-(1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-h][1,6]naphthyridin-5-oxo)benzaldehyde

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1039/c2ob26710a

Reference yield:

: 1223081-81-9
5-bromo-8-(((1r,4r)-4-((tert-butoxycarbonyl)amino)cyclohexyl)amino)-1,6-naphthyridine-7-carboxylic acid

: 1422434-16-9
4-(1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-h][1,6]naphthyridin-5-oxo)benzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 90 °C

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 110 °C

4: trifluoroacetic acid / dichloromethane / 20 °C

With diphenyl phosphoryl azide; potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene; 3: |Williamson Ether Synthesis;
DOI:10.1039/c2ob26710a