1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-(4-(hydroxymethyl)phenoxy)-1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)one

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Chemical Name:1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-(4-(hydroxymethyl)phenoxy)-1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)one
CAS No.:1422434-18-1
Molecular Formula:C₂₉H₂₇Cl₂N₅O₃
Molecular Weight:564.471
Hs Code.:

Synonyms:1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-(4-(hydroxymethyl)phenoxy)-1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)one

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Chemical Property of 1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-(4-(hydroxymethyl)phenoxy)-1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)one

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Technology Process of 1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-(4-(hydroxymethyl)phenoxy)-1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)one

There total 8 articles about 1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-(4-(hydroxymethyl)phenoxy)-1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.6%

: 1422434-16-9
4-(1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-h][1,6]naphthyridin-5-oxo)benzaldehyde

: 1422434-18-1
1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-(4-(hydroxymethyl)phenoxy)-1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)one

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; at 20 ℃; for 6h;

Reference yield:

: C₃₄H₃₅Cl₂N₅O₅

: 1422434-18-1
1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-(4-(hydroxymethyl)phenoxy)-1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1039/c2ob26710a

Reference yield:

: 1223081-81-9
5-bromo-8-(((1r,4r)-4-((tert-butoxycarbonyl)amino)cyclohexyl)amino)-1,6-naphthyridine-7-carboxylic acid

: 1422434-18-1
1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-(4-(hydroxymethyl)phenoxy)-1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)one

Guidance literature:: Multi-step reaction with 5 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 90 °C

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 12 h / 110 °C

4: sodium tetrahydroborate / tetrahydrofuran / 2 h / 20 °C

5: trifluoroacetic acid / dichloromethane / 20 °C

With sodium tetrahydroborate; diphenyl phosphoryl azide; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 3: |Williamson Ether Synthesis;
DOI:10.1039/c2ob26710a