[(1R,2R,4R,5R)-4-acetoxy-2-[[7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carbonyl]amino]-5-dimethylamino-cyclohexyl] acetate

Base Information

Chemical Name:[(1R,2R,4R,5R)-4-acetoxy-2-[[7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carbonyl]amino]-5-dimethylamino-cyclohexyl] acetate
CAS No.:1280664-80-3
Molecular Formula:C₃₅H₄₇N₇O₇
Molecular Weight:677.801
Hs Code.:

[(1R,2R,4R,5R)-4-acetoxy-2-[[7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carbonyl]amino]-5-dimethylamino-cyclohexyl] acetate

Synonyms:[(1R,2R,4R,5R)-4-acetoxy-2-[[7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carbonyl]amino]-5-dimethylamino-cyclohexyl] acetate

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Chemical Property of [(1R,2R,4R,5R)-4-acetoxy-2-[[7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carbonyl]amino]-5-dimethylamino-cyclohexyl] acetate

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Technology Process of [(1R,2R,4R,5R)-4-acetoxy-2-[[7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carbonyl]amino]-5-dimethylamino-cyclohexyl] acetate

There total 18 articles about [(1R,2R,4R,5R)-4-acetoxy-2-[[7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carbonyl]amino]-5-dimethylamino-cyclohexyl] acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.8%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1280665-78-2
[(1R,2R,4R,5R)-4-acetoxy-5-(tert-butoxycarbonylamino)-2-[[7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carbonyl]amino]cyclohexyl] acetate

: 1280664-80-3
[(1R,2R,4R,5R)-4-acetoxy-2-[[7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carbonyl]amino]-5-dimethylamino-cyclohexyl] acetate

Guidance literature:: [(1R,2R,4R,5R)-4-acetoxy-5-(tert-butoxycarbonylamino)-2-[[7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carbonyl]amino]cyclohexyl] acetate; With hydrogenchloride; In 1,4-dioxane; dichloromethane; for 0.5h; Inert atmosphere;

formaldehyd; In acetonitrile; at 20 - 30 ℃; for 0.5h; Inert atmosphere;

With water; sodium tris(acetoxy)borohydride; In acetonitrile; for 12h; Inert atmosphere;

Reference yield:

: 620604-44-6
methyl 7-nitrobenzofuran-4-carboxylate

: 1280664-80-3
[(1R,2R,4R,5R)-4-acetoxy-2-[[7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carbonyl]amino]-5-dimethylamino-cyclohexyl] acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 - 30 °C / 2280.15 Torr / Cooling with ice

2.1: toluene-4-sulfonic acid / Methyl isobutyl carbinol / 6 h / Reflux; Inert atmosphere

3.1: water; lithium hydroxide / methanol / 3 h / Reflux; Inert atmosphere

3.2: pH 2

4.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 2 h / 20 - 30 °C / Inert atmosphere

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 0.5 h / Inert atmosphere

5.2: 0.5 h / 20 - 30 °C / Inert atmosphere

5.3: 12 h / Inert atmosphere

With hydrogenchloride; water; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; palladium 10% on activated carbon; In 1,4-dioxane; methanol; Methyl isobutyl carbinol; dichloromethane;

Reference yield:

: 713-52-0
methyl 3-hydroxy-4-nitrobenzoate

: 1280664-80-3
[(1R,2R,4R,5R)-4-acetoxy-2-[[7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carbonyl]amino]-5-dimethylamino-cyclohexyl] acetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / acetonitrile / 3 h / Reflux; Inert atmosphere

2.1: 3 h / 190 °C / Inert atmosphere

3.1: Oxone / dichloromethane; methanol / 1.17 h / -78 °C / Inert atmosphere

3.2: 3 h / 20 °C / Inert atmosphere

4.1: phosphoric acid / 0.33 h / 100 °C / Inert atmosphere

5.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 - 30 °C / 2280.15 Torr / Cooling with ice

6.1: toluene-4-sulfonic acid / Methyl isobutyl carbinol / 6 h / Reflux; Inert atmosphere

7.1: water; lithium hydroxide / methanol / 3 h / Reflux; Inert atmosphere

7.2: pH 2

8.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 2 h / 20 - 30 °C / Inert atmosphere

9.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 0.5 h / Inert atmosphere

9.2: 0.5 h / 20 - 30 °C / Inert atmosphere

9.3: 12 h / Inert atmosphere

With hydrogenchloride; Oxone; phosphoric acid; water; hydrogen; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; palladium 10% on activated carbon; In 1,4-dioxane; methanol; Methyl isobutyl carbinol; dichloromethane; acetonitrile;